Reference Report

Reference
Citation	de Velasco, B., Erclik, T., Shy, D., Sclafani, J., Lipshitz, H., McInnes, R., Hartenstein, V. (2007). Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain. Dev. Biol. 302(1): 309--323. (Export to RIS)
FlyBase ID	FBrf0193772
Publication Type	Research paper
PubMed ID	17070515
PubMed Abstract	The central neuroendocrine system in the Drosophila brain includes two centers, the pars intercerebralis (PI) and pars lateralis (PL). The PI and PL contain neurosecretory cells (NSCs) which project their axons to the ring gland, a complex of peripheral endocrine glands flanking the aorta. We present here a developmental and genetic study of the PI and PL. The PI and PL are derived from adjacent neurectodermal placodes in the dorso-medial head. The placodes invaginate during late embryogenesis and become attached to the brain primordium. The PI placode and its derivatives express the homeobox gene Dchx1 and can be followed until the late pupal stage. NSCs labeled by the expression of Drosophila insulin-like peptide (Dilp), FMRF, and myomodulin form part of the Dchx1 expressing PI domain. NSCs of the PL can be followed throughout development by their expression of the adhesion molecule FasII. Decapentaplegic (Dpp), secreted along the dorsal midline of the early embryo, inhibits the formation of the PI and PL placodes; loss of the signal results in an unpaired, enlarged placodeal ectoderm. The other early activated signaling pathway, EGFR, is positively required for the maintenance of the PI placode. Of the dorso-medially expressed head gap genes, only tailless (tll) is required for the specification of the PI. Absence of the corpora cardiaca, the endocrine gland innervated by neurosecretory cells of the PI and PL, does not affect the formation of the PI/PL, indicating that inductive stimuli from their target tissue are not essential for early PI/PL development.
DOI	10.1016/j.ydbio.2006.09.035
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (15)
	Avic\GFP^{S65T.Scer\UAS} dpp^H46 Ecol\lacZ^{Scer\UAS.HLHm5} Egfr^f5 fkh⁶ gl² gt^X11 hh²¹ Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} oc⁷⁶ Scer\GAL4^Cha.7.4 Scer\GAL4^nrv2.PS Scer\GAL4^Vsx1-MzVum so³ tll^l49
Constructs (5)
	P{Cha-GAL4.7.4} P{nrv2-GAL4.S} P{UAS-GFP.S65T} P{UAS-m5-lacZ} P{UAS-mCD8::GFP.L}
Genes (23)
	Avic\GFP crb dpp E(spl)m5-HLH Ecol\lacZ Egfr elav Fas2 fkh Fmrf gl gt hh Ilp1 Mmus\Cd8a Nrt oc Rx Scer\GAL4 sim so tll Vsx1
Insertions (1)
	P{GawB}MzVum