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Reference Report
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| Citation | Cao, C., Liu, Y., Lehmann, M. (2007). Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death. J. Cell Biol. 176(6): 843--852. (Export to RIS) | ||
| FlyBase ID | FBrf0193919 | ||
| Publication Type | Research paper | ||
| PubMed ID | 17339378 | ||
| PubMed Abstract | Cell death during Drosophila melanogaster metamorphosis is controlled by the steroid hormone 20-hydroxyecdysone (20E). Elements of the signaling pathway that triggers death are known, but it is not known why some tissues, and not others, die in response to a particular hormone pulse. We found that loss of the tissue-specific transcription factor Fork head (Fkh) is both required and sufficient to specify a death response to 20E in the larval salivary glands. Loss of fkh itself is a steroid-controlled event that is mediated by the 20E-induced BR-C gene, and that renders the key death regulators hid and reaper hormone responsive. These results implicate the D. melanogaster FOXA orthologue Fkh with a novel function as a competence factor for steroid-controlled cell death. They explain how a specific tissue is singled out for death, and why this tissue survives earlier hormone pulses. More generally, they suggest that cell identity factors like Fkh play a pivotal role in the normal control of developmental cell death. | ||
| DOI | 10.1083/jcb.200611155 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | J. Cell Biol. | ||
| Title | Journal of Cell Biology | ||
| Publication Year | 1966- | ||
| ISBN/ISSN | 0021-9525 | ||
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Data from Reference
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| Alleles (3)
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| Constructs (2)
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| Genes (23)
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| Natural transposons (1)
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