Reference Report

Reference
Citation	Jiang, J., Benson, E., Bausek, N., Doggett, K., White-Cooper, H. (2007). Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with Always early. Development 134(8): 1549--1559. (Export to RIS)
FlyBase ID	FBrf0194011
Publication Type	Research paper
PubMed ID	17360778
PubMed Abstract	During male gametogenesis, a developmentally regulated and cell type-specific transcriptional programme is activated in primary spermatocytes to prepare for differentiation of sperm. The Drosophila aly-class meiotic-arrest loci (aly, comr, achi/vis and topi) are essential for activation of transcription of many differentiation-specific genes, and several genes important for meiotic cell cycle progression, thus linking meiotic divisions to cellular differentiation during spermatogenesis. Protein interaction studies suggest that the aly-class gene products form a chromatin-associated complex in primary spermatocytes. We identify, clone and characterise a new aly-class meiotic-arrest gene, tombola (tomb), which encodes a testis-specific CXC-domain protein that interacts with Aly. The tomb mutant phenotype is more like that of aly and comr mutants than that of achi/vis or topi mutants in terms of target gene profile and chromosome morphology. tomb encodes a chromatin-associated protein required for localisation of Aly and Comr, but not Topi, to chromatin Reciprocally, aly and comr, but not topi or achi/vis, are required to maintain the normal localisation of Tomb. tomb and aly might be components of a complex paralogous to the Drosophila dREAM/Myb-MuvB and C. elegans DRM transcriptional regulatory complexes.
DOI	10.1242/dev.000521
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (2)
	Df(2L)cl-h1 Df(2L)cl-h3
Alleles (13)
	achi^Z3922 aly⁵ Cap-D3^EY00456 Cap-D3^GS12862 comr^z1340 mia^unspecified nht^Z5946 Scer\GAL4^{bam.T:Hsim\VP16} T:Avic\GFP^EGFP tomb^GS12862 tomb^{Scer\UAS.T:Avic\GFP-EGFP} topi^Z3-2139 vis^Z3922
Constructs (3)
	P{bam-GAL4:VP16} P{GSV6} P{UAS-EGFP-tomb}
Genes (22)
	achi aly Cap-D3 CG3330 CG3927 CG7277 CG12907 CG14015 CG31648 CG31915 comr CycB mia mip120 Mst87F nht polo PPYR1 Scer\GAL4 tomb topi vis
Insertions (2)
	P{EPgy2}Cap-D3^EY00456 P{GSV6}tomb^GS12862
Natural transposons (1)
	P-element