Reference Report

Reference
Citation	Arkov, A.L., Wang, J.Y.S., Ramos, A., Lehmann, R. (2006). The role of Tudor domains in germline development and polar granule architecture. Development 133(20): 4053--4062. (Export to RIS)
FlyBase ID	FBrf0194255
Publication Type	Research paper
PubMed ID	16971472
PubMed Abstract	Tudor domains are found in many organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. Here, we present evidence for the involvement of specific Tudor domains in germline development. Drosophila Tudor, the founder of the Tudor domain family, contains 11 Tudor domains and is a component of polar granules and nuage, electron-dense organelles characteristic of the germline in many organisms, including mammals. In this study, we investigated whether the 11 Tudor domains fulfil specific functions for polar granule assembly, germ cell formation and abdomen formation. We find that even a small number of non-overlapping Tudor domains or a substantial reduction in overall Tudor protein is sufficient for abdomen development. In stark contrast, we find a requirement for specific Tudor domains in germ cell formation, Tudor localization and polar granule architecture. Combining genetic analysis with structural modeling of specific Tudor domains, we propose that these domains serve as ;docking platforms' for polar granule assembly.
DOI	10.1242/dev.02572
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (1)
	Df(2R)Pu^rP133a
Alleles (22)
	tud¹ tud⁴ tud^A1 tud^A7 tud^A10 tud^A14 tud^A36 tud^A47 tud^B42 tud^B45 tud^C3 tud^C8 tud^C11 tud^C30 tud^C53 tud^C67 tud^C73 tud^{nos.T:Ivir\HA1} tud^{Δ1.nos.T:Ivir\HA1} tud^{Δ2.nos.T:Ivir\HA1} tud^{Δ3.nos.T:Ivir\HA1} w^+mC
Constructs (4)
	P{nos-mini-tud.Δ1} P{nos-mini-tud.Δ2} P{nos-mini-tud.Δ3} P{nos-tud.HA}
Genes (7)
	gcl nos pgc T:Ivir\HA1 tud vas w
Natural transposons (1)
	P-element