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Citation
Casal, J., Lawrence, P.A., Struhl, G. (2006). Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity.  Development 133(22): 4561--4572.
FlyBase ID
FBrf0194266
Publication Type
Research paper
Abstract
Planar polarity is a fundamental property of epithelia in animals and plants. In Drosophila it depends on at least two sets of genes: one set, the Ds system, encodes the cadherins Dachsous (Ds) and Fat (Ft), as well as the Golgi protein Four-jointed. The other set, the Stan system, encodes Starry night (Stan or Flamingo) and Frizzled. The prevailing view is that the Ds system acts via the Stan system to orient cells. However, using the Drosophila abdomen, we find instead that the two systems operate independently: each confers and propagates polarity, and can do so in the absence of the other. We ask how the Ds system acts; we find that either Ds or Ft is required in cells that send information and we show that both Ds and Ft are required in the responding cells. We consider how polarity may be propagated by Ds-Ft heterodimers acting as bridges between cells.
PubMed ID
PubMed Central ID
PMC2747022 (PMC) (EuropePMC)
Related Publication(s)
Review
Fat and frizzled.
Anonymous, 2006, Nature 444(7116): 126 [FBrf0200018]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Development
    Title
    Development
    Publication Year
    1987-
    ISBN/ISSN
    0950-1991
    Data From Reference