Reference Report

Reference
Citation	Tsuda, L., Kaido, M., Lim, Y.M., Kato, K., Aigaki, T., Hayashi, S. (2006). An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila. EMBO J. 25(13): 3191--3202. (Export to RIS)
FlyBase ID	FBrf0194300
Publication Type	Research paper
PubMed ID	16763555
PubMed Abstract	The corepressor complex that includes Ebi and SMRTER is a target of epidermal growth factor (EGF) and Notch signaling pathways and regulates Delta (Dl)-mediated induction of support cells adjacent to photoreceptor neurons of the Drosophila eye. We describe a mechanism by which the Ebi/SMRTER corepressor complex maintains Dl expression. We identified a gene, charlatan (chn), which encodes a C2H2-type zinc-finger protein resembling human neuronal restricted silencing factor/repressor element RE-1 silencing transcription factor (NRSF/REST). The Ebi/SMRTER corepressor complex represses chn transcription by competing with the activation complex that includes the Notch intracellular domain (NICD). Chn represses Dl expression and is critical for the initiation of eye development. Thus, under EGF signaling, double negative regulation mediated by the Ebi/SMRTER corepressor complex and an NRSF/REST-like factor, Chn, maintains inductive activity in developing photoreceptor cells by promoting Dl expression.
DOI	10.1038/sj.emboj.7601179
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Language of Publication	English
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Publication Type	Journal
Abbreviation	EMBO J.
Title	The EMBO Journal
Publication Year	1982-
ISBN/ISSN	0261-4189
Data from Reference
Alleles (24)
	chn¹ chn⁹ chn^{C1049A.Scer\UAS} chn^{C.Scer\UAS.T:Zzzz\FLAG} chn^{fl.Scer\UAS.T:Zzzz\FLAG} chn^GS2112 chn^GS11450 chn^GS17605 chn^GS17892 chn^{N.Scer\UAS.T:Zzzz\FLAG} chn^Scer\UAS.cTa CoRest^T:Ivir\HA1 CycE^AR95 ebi^1-334.GMR ebi¹¹ ebi^E4 ebi^P7 mus209⁷⁷⁵ Scer\GAL4^da.G32 Scer\GAL4^GMR.PF Su(H)¹ Su(H)² tkv⁴ w^+mC
Constructs (7)
	P{GAL4-da.G32} P{GAL4-ninaE.GMR} P{GMR-ebi.1-334} P{GSV1} P{GSV6} P{UAS-chn.C1049A} P{UAS-chn.T}
Genes (40)
	AlCR2 Arr2 bi brk chn CoRest ct CycE Dcp-1 Dfd Dg Dl E(spl)mδ-HLH eag ebi elav emc h HmgZ Hsp27 kek2 Lar lkb1 Mnt mus209 N nAcRβ-64B Obp83b orb shakB slv Smr Socs16D spir Su(H) T:Zzzz\FLAG Tehao tinc tkv w
Insertions (4)
	P{GSV1}chn^GS2112 P{GSV6}chn^GS11450 P{GSV6}chn^GS17605 P{GSV6}chn^GS17892
Natural transposons (1)
	P-element