Reference Report

Reference
Citation	Mueller, J.L., Page, J.L., Wolfner, M.F. (2007). An ectopic expression screen reveals the protective and toxic effects of Drosophila seminal fluid proteins. Genetics 175(2): 777--783. (Export to RIS)
FlyBase ID	FBrf0194341
Publication Type	Research paper
PubMed ID	17110486
PubMed Abstract	In Drosophila melanogaster, seminal fluid regulates the reproductive and immune responses of mated females. Some seminal fluid proteins may provide protective functions to mated females, such as antimicrobial activity and/or stimulation of antimicrobial gene expression levels, while others appear to have negative effects, contributing to a "cost of mating." To identify seminal proteins that could participate in these phenomena, we used a systemic ectopic expression screen to test the effects on unmated females of proteins normally produced by the male accessory gland (Acps). Of the 21 ectopically expressed Acps that we tested for ability to assist in the clearance of a bacterial infection with Serratia marcescens, 3 Acps significantly reduced the bacterial counts of infected females, suggesting a protective role. Of the 23 Acps that we tested for toxicity, 3 were toxic, including one that has been implicated in the cost of mating in another study. We also tested ectopic expression females for other Acp-induced effects, but found no additional Acps that affected egg laying or receptivity upon ectopic expression.
DOI	10.1534/genetics.106.065318
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Alleles (30)
	Acp29AB^Scer\UAS.cLa Acp53Ea^Scer\UAS.cMa Acp62F^Scer\UAS.cLa Acp70A^Scer\UAS.cKa Acp76A^Scer\UAS.cMa BG642167^Scer\UAS.cMa BG642312^Scer\UAS.cMa CG4847^Scer\UAS.cMa CG6168^Scer\UAS.cMa CG6555^Scer\UAS.cMa CG9029^Scer\UAS.cMa CG9997^Scer\UAS.cMa CG10433^Scer\UAS.cMa CG11664^Scer\UAS.cMa CG11864^Scer\UAS.cMa CG13309^Scer\UAS.cMa CG34129^Scer\UAS.cMa CG42564^Scer\UAS.cMa msopa^Scer\UAS.cMa Mst57Da^Scer\UAS.cMa Mst57Db^Scer\UAS.cMa Mst57Dc^Scer\UAS.cMa Rel^E20 Scer\GAL4^hs.PB Scer\GAL4^αTub84B.PL Spn28F^Scer\UAS.cMa Spn38F^Scer\UAS.cMa Spn53F^Scer\UAS.cMa Spn77Bc^Scer\UAS.cMa w^+mC
Constructs (28)
	P{GAL4-Hsp70.PB} P{tubP-GAL4} P{UAS-Acp29AB.L} P{UAS-Acp53Ea.M} P{UAS-Acp62F.L} P{UAS-Acp70A.K} P{UAS-Acp76A.M} P{UAS-BG642167.M} P{UAS-BG642312.M} P{UAS-CG4847.M} P{UAS-CG6168.M} P{UAS-CG6289.M} P{UAS-CG6555.M} P{UAS-CG9029.M} P{UAS-CG9997.M} P{UAS-CG10433.M} P{UAS-CG10956.M} P{UAS-CG11664.M} P{UAS-CG11864.M} P{UAS-CG13309.M} P{UAS-CG34129.M} P{UAS-CG42564.M} P{UAS-msopa.M} P{UAS-Mst57Da.M} P{UAS-Mst57Db.M} P{UAS-Mst57Dc.M} P{UAS-Spn2.M} P{UAS-Spn3.M}
Genes (29)
	Acp29AB Acp53Ea Acp62F Acp70A Acp76A BG642167 BG642312 CG4847 CG6168 CG6555 CG9029 CG9997 CG10433 CG11664 CG11864 CG13309 CG34129 CG42564 msopa Mst57Da Mst57Db Mst57Dc Rel Scer\GAL4 Spn28F Spn38F Spn53F Spn77Bc w
Insertions (3)
	P{UAS-CG6289.M}CF.2 P{UAS-CG6289.M}DM P{UAS-Spn2.M}BM.1
Natural transposons (1)
	P-element