Reference Report

Reference
Citation	Culi, J., Aroca, P., Modolell, J., Mann, R.S. (2006). jing is required for wing development and to establish the proximo-distal axis of the leg in Drosophila melanogaster. Genetics 173(1): 255--266. (Export to RIS)
FlyBase ID	FBrf0194382
Publication Type	Research paper
PubMed ID	16510782
PubMed Abstract	The establishment of the proximo-distal (PD) axis in the legs of Drosophila melanogaster requires the expression of a nested set of transcription factors that are activated in discreet domains by secreted signaling molecules. The precise regulation of these transcription factor domains is critical for generating the stereotyped morphological characteristics that exist along the PD axis, such as the positioning of specific bristle types and leg joints. Here we provide evidence that the Zn-finger protein encoded by the gene jing is critical for PD axis formation in the Drosophila legs. Our data suggest that jing represses transcription and that it is necessary to keep the proximal gene homothorax (hth) repressed in the medial domain of the PD axis. We further show that jing is also required for alula and vein development in the adult wing. In the wing, Jing is required to repress another proximal gene, teashirt (tsh), in a small domain that will give rise to the alula. Interestingly, we also demonstrate that two other genes affecting alula development, Alula and elbow, also exhibit tsh derepression in the same region of the wing disc as jing- clones. Finally, we show that jing genetically interacts with several members of the Polycomb (Pc) group of genes during development. Together, our data suggest that jing encodes a transcriptional repressor that may participate in a subset of Pc-dependent activities during Drosophila appendage development.
DOI	10.1534/genetics.106.056341
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (2)
	Df(2R)cn88b Df(2R)vg-D
Alleles (20)
	Alu^56c Asx^XF23 Ecol\lacZ^arm.PV Ecol\lacZ^jing-01094 elA¹ hth^k1 jing^22F3 jing^47H6 jing⁰¹⁰⁹⁴ jing^k03404 jing^Scer\UAS.cCa jing^unspecified jing^{Znf.E1A.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC,T:Adeno5\E1a} jing^{Znf.EnR.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC,T:Rep-en} jing^{Znf.Scer\UAS.T:Uuuu\nls6,T:Hsap\MYC} Pc¹⁵ Pcl¹⁵ Scer\GAL4^en-e16E Scer\GAL4^tub.PU w^+mC
Constructs (6)
	P{arm-lacZ.V} P{tub-GAL4.U} P{UAS-jing.FL} P{UAS-jing.Znf.E1A} P{UAS-jing.Znf.EnR} P{UAS-jing.Znf}
Genes (18)
	Alu Asx dac Dll Ecol\lacZ elA hth jing Pc Pcl Scer\GAL4 T:Adeno5\E1a T:Hsap\MYC T:Uuuu\nls6 tsh Ubx w wg
Insertions (3)
	P{en2.4-GAL4}e16E P{lacW}jing^k03404 P{PZ}jing⁰¹⁰⁹⁴
Natural transposons (1)
	P-element