Reference Report

Reference
Citation	de Navas, L.F., Garaulet, D.L., Sanchez-Herrero, E. (2006). The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway. Development 133(22): 4495--4506. (Export to RIS)
FlyBase ID	FBrf0194425
Publication Type	Research paper
PubMed ID	17050628
PubMed Abstract	The halteres and wings of Drosophila are homologous thoracic appendages, which share common positional information provided by signaling pathways. The activity in the haltere discs of the Ultrabithorax (Ubx) Hox gene establishes the differences between these structures, their different size being an obvious one. We show here that Ubx regulates the activity of the Decapentaplegic (Dpp) signaling pathway at different levels, and that this regulation is instrumental in establishing the size difference. Ubx downregulates dpp transcription and reduces Dpp diffusion by repressing the expression of master of thick veins and division abnormally delayed and by increasing the levels of thick veins, one of the Dpp receptors. Our results suggest that modulation in Dpp expression and spread accounts, in part, for the different size of halteres and wings.
DOI	10.1242/dev.02609
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (3)
	Df(2L)cl-h1 Df(2L)tkv2 Df(3R)Ubx109
Alleles (30)
	Avic\GFP^{S65T.Scer\UAS} dally^Scer\UAS.cJa dpp^d5 dpp^d12 dpp^Scer\UAS.cCa dpp^{Scer\UAS.E.T:Avic\GFP-EGFP} Ecol\lacZ^bi-Pol-1 Ecol\lacZ^dally-06464 Ecol\lacZ^dpp-10638 Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^hh-P30 Ecol\lacZ^sbb-k00702 Ecol\lacZ^tkv-P906 sbb^Scer\UAS.cTa Scer\GAL4^ap-md544 Scer\GAL4^Bx-MS1096 Scer\GAL4^dpp.blk1 Scer\GAL4^en-e16E Scer\GAL4^ptc-559.1 Scer\GAL80^ts.αTub84B tkv^{1ΔGSK.Scer\UAS} tkv^{Q253D.Scer\UAS.cNb} tkv^Scer\UAS.cLa Ubx^6.28 Ubx¹³⁰ Ubx^bx-3 Ubx^Cbx-Twt Ubx^{dsRNA.IR.Scer\UAS} Ubx^pbx-1 Ubx^Scer\UAS.cCa
Constructs (13)
	P{BS3.0} P{GAL4-dpp.blk1} P{tubP-GAL80^ts} P{UAS-dally.J} P{UAS-dpp.C} P{UAS-dpp.GFP.E} P{UAS-GFP.S65T} P{UAS-sbb.T} P{UAS-tkv.1ΔGSK} P{UAS-tkv.La} P{UAS-tkv.Q253D.Nb} P{UAS-Ubx.Ia.C} P{UAS-Ubx.IR}
Genes (13)
	Avic\GFP bi dally dlp dpp Ecol\lacZ en Mad sbb Scer\GAL4 Scer\GAL80 tkv Ubx
Insertions (10)
	P{en2.4-GAL4}e16E P{GawB}ap^md544 P{GawB}Bx^MS1096 P{GawB}ptc^559.1 P{lacW}bi^Pol-1 P{lacW}sbb^k00702 P{PZ}dally⁰⁶⁴⁶⁴ P{PZ}dpp¹⁰⁶³⁸ P{PZ}hh^P30 P{PZ}tkv^P906