Reference Report

Reference
Citation	Kuranaga, E., Kanuka, H., Tonoki, A., Takemoto, K., Tomioka, T., Kobayashi, M., Hayashi, S., Miura, M. (2006). Drosophila IKK-related kinase regulates nonapoptotic function of caspases, via degradation of IAPs. Cell 126(3): 583--596. (Export to RIS)
FlyBase ID	FBrf0194448
Publication Type	Research paper
PubMed ID	16887178
PubMed Abstract	Caspase activation has been extensively studied in the context of apoptosis. However, caspases also control other cellular functions, although the mechanisms regulating caspases in nonapoptotic contexts remain obscure. Drosophila IAP1 (DIAP1) is an endogenous caspase inhibitor that is crucial for regulating cell death during development. Here we describe Drosophila IKK-related kinase (DmIKKvarepsilon) as a regulator of caspase activation in a nonapoptotic context. We show that DmIKKvarepsilon promotes degradation of DIAP1 through direct phosphorylation. Knockdown of DmIKKvarepsilon in the proneural clusters of the wing imaginal disc, in which nonapoptotic caspase activity is required for proper sensory organ precursor (SOP) development, stabilizes endogenous DIAP1 and affects Drosophila SOP development. Our results demonstrate that DmIKKvarepsilon is a determinant of DIAP1 protein levels and that it establishes the threshold of activity required for the execution of nonapoptotic caspase functions.
DOI	10.1016/j.cell.2006.05.048
Related Publication(s)
Erratum	Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs (vol 126, pg 583, 2006). Kuranaga et al., 2006, Cell 126(4): 811 [FBrf0192540]
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (8)
	Df(2L)DS6 Df(2L)pr-A20 Df(2L)Sd77 Df(2L)TW1 Df(2L)TW2 Df(2L)TW65 Df(2L)TW161 Df(3L)H99
Alleles (29)
	Avic\GFP^{SCAT3.Scer\UAS} Avic\GFP^Scer\UAS.cUa Ecol\lacZ^{dsRNA.IR.Scer\UAS} Ecol\lacZ^Scer\UAS.cUa Hsap\TBK1^{K41M.Scer\UAS.T:Hsap\MYC} Hsap\TBK1^{Scer\UAS.T:Hsap\MYC} ik2¹ ik2³ ik2⁵ ik2^{D160N.Scer\UAS.T:Hsap\MYC} ik2^{dsRNA.Scer\UAS} ik2^{G19R.Scer\UAS.T:Hsap\MYC} ik2^{G250D.Scer\UAS.T:Hsap\MYC} ik2^hs.PK ik2^Scer\UAS.cKa ik2^{Scer\UAS.T:Hsap\MYC} ik2^{ΔUbl.Scer\UAS.T:Hsap\MYC} l(2)38Eb⁵¹ l(2)38Eb⁵⁴ Nc^{C318G.Scer\UAS} rpr^GMR.PH rpr^hs.PW Scer\GAL4^Act5C.PHb Scer\GAL4^Act5C.PI Scer\GAL4^en-e16E Scer\GAL4^GMR.PF Scer\GAL4^sca-P309 th^{Scer\UAS.T:Zzzz\FLAG} w^+mC
Constructs (17)
	P{Act5C-GAL4.Hb} P{Act5C-GAL4} P{GAL4-ninaE.GMR} P{GMR-rpr.H} P{UAS-dronc.C318G} P{UAS-GFP.U} P{UAS-ik2.D160N} P{UAS-ik2.dsRNA} P{UAS-ik2.G19R} P{UAS-ik2.G250D} P{UAS-ik2.K} P{UAS-ik2.MYC} P{UAS-ik2.ΔUbl} P{UAS-lacZ.IR} P{UAS-lacZ.U} P{UAS-SCAT3} P{UAS-th.FLAG}
Genes (15)
	Avic\GFP CG2611 dia Ecol\lacZ Hr38 Hsap\TBK1 ik2 l(2)38Eb Nc rpr Scer\GAL4 sens T:Hsap\MYC th w
Insertions (2)
	P{en2.4-GAL4}e16E P{GAL4}sca^P309
Natural transposons (1)
	P-element