Reference Report

Reference
Citation	Sun, X., Morozova, T., Sonnenfeld, M. (2006). Glial and neuronal functions of the Drosophila homolog of the human SWI/SNF gene ATR-X (DATR-X) and the jing zinc-finger gene specify the lateral positioning of longitudinal glia and axons. Genetics 173(3): 1397--1415. (Export to RIS)
FlyBase ID	FBrf0194564
Publication Type	Research paper
External Crossreferences
PubMed ID	16648585
PubMed Abstract	Neuronal-glial communication is essential for constructing the orthogonal axon scaffold in the developing Drosophila central nervous system (CNS). Longitudinal glia (LG) guide extending commissural and longitudinal axons while pioneer and commissural neurons maintain glial survival and positioning. However, the transcriptional regulatory mechanisms controlling these processes are not known. Previous studies showed that the midline function of the jing C2H2-type zinc-finger transcription factor was only partially required for axon scaffold formation in the Drosophila CNS. We therefore screened for gain-of-function enhancers of jing gain of function in the eye and identified the Drosophila homolog of the disease gene of human alpha-thalassemia/mental retardation X-linked (ATR-X) as well as other genes with potential roles in gene expression, translation, synaptic transmission, and cell cycle. jing and DATR-X reporter genes are expressed in both CNS neurons and glia, including the LG. Coexpression of jing and DATR-X in embryonic neurons synergistically affects longitudinal connective formation. During embryogenesis, jing and DATR-X have autonomous and nonautonomous roles in the lateral positioning of LG, neurons, and longitudinal axons as shown by cell-specific knockdown of gene expression. jing and DATR-X are also required autonomously for glial survival. jing and DATR-X mutations show synergistic effects during longitudinal axon formation suggesting that they are functionally related. These observations support a model in which downstream gene expression controlled by a potential DATR-X-Jing complex facilitates cellular positioning and axon guidance, ultimately allowing for proper connectivity in the developing Drosophila CNS.
BIOSIS ID	2006.609881
Zoological Record ID
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Secondary IDs
Language of Publication	English
Additional Languages of Abstract
ISBN
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Editors
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (1)
	Df(2R)ST1
Alleles (29)
	Atx2^EP3145 CG15514^EP1005 CG32137^EP3705 cnc^EP3258 D1^EP473 Ecol\lacZ^jing.1.5 Ecol\lacZ^XNP.593 EP893^EP893 EP3303^EP3303 EP3377^EP3377 EP3916^EP3916 jigr1^EP3354 jing³ jing^{dsRNA.Scer\UAS.WIZ} jing^Scer\UAS.cSa kay^EP3084 kibra^EP3205 lap^EP3060 nuf^EP3339 pUf68^EP3058 Scer\GAL4^arm.PS Scer\GAL4^btl.PS Scer\GAL4^elav.PLu Scer\GAL4^gcm-rA87.P Scer\GAL4^GMR.PF Scer\GAL4^prd.RG1 w^+mC XNP^{dsRNA.Scer\UAS.WIZ} XNP^EP635
Constructs (11)
	P{EP} P{GAL4-arm.S} P{GAL4-btl.S} P{GAL4-elav.L} P{GAL4-ninaE.GMR} P{GAL4-prd.F} P{jing-lacZ.1.5} P{UAS-jing.RNAi.WIZ} P{UAS-jing.S} P{UAS-XNP.RNAi.WIZ} P{XNP-lacZ.593}
Genes (24)
	Atx2 CG15514 CG32137 cnc D1 Ecol\lacZ EP893 EP3303 EP3377 EP3916 Fas2 jigr1 jing kay Kdm2 kibra lap nuf pUf68 repo robo Scer\GAL4 w XNP
Insertions (26)
	P{EP}Atx2^EP3145 P{EP}CG15514^EP1005 P{EP}CG32137^EP3705 P{EP}cnc^EP3258 P{EP}D1^EP473 P{EP}EP893^EP893 P{EP}EP1096 P{EP}EP3303^EP3303 P{EP}EP3377^EP3377 P{EP}EP3916^EP3916 P{EP}jigr1^EP3354 P{EP}kay^EP3084 P{EP}kibra^EP3205 P{EP}lap^EP3060 P{EP}nuf^EP3339 P{EP}pUf68^EP3058 P{EP}XNP^EP635 P{GawB}gcm^rA87.P P{UAS-jing.RNAi.WIZ}006 P{UAS-jing.RNAi.WIZ}NA2 P{UAS-jing.RNAi.WIZ}NC1A P{UAS-jing.RNAi.WIZ}ORO3 P{UAS-XNP.RNAi.WIZ}022 P{UAS-XNP.RNAi.WIZ}26-MO2 P{UAS-XNP.RNAi.WIZ}28-MO1 P{UAS-XNP.RNAi.WIZ}28-MO2
Natural transposons (1)
	P-element