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Citation
Lee, J.H., Koh, H., Kim, M., Park, J., Lee, S.Y., Lee, S., Chung, J. (2006). JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila.  Cell Death Differ. 13(7): 1110--1122.
FlyBase ID
FBrf0194576
Publication Type
Research paper
Abstract

Although recent progresses have unveiled the diverse in vivo functions of LKB1, detailed molecular mechanisms governing these processes still remain enigmatic. Here, we showed that Drosophila LKB1 negatively regulates organ growth by caspase-dependent apoptosis, without affecting cell size and cell cycle progression. Through genetic screening for LKB1 modifiers, we discovered the JNK pathway as a novel component of LKB1 signaling; the JNK pathway was activated by LKB1 and mediated the LKB1-dependent apoptosis. Consistently, LKB1-null mutant was defective in embryonic apoptosis and displayed a drastic hyperplasia in the central nervous system; these phenotypes were fully rescued by ectopic JNK activation as well as wild-type LKB1 expression. Furthermore, inhibition of LKB1 resulted in epithelial morphogenesis failure, which was associated with a decrease in JNK activity. Collectively, our studies unprecedentedly elucidate JNK as the downstream mediator of the LKB1-dependent apoptosis, and provide a new paradigm for understanding the diverse LKB1 functions in vivo.

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PubMed Central ID
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Secondary IDs
  • FBrf0189947
Language of Publication
English
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Parent Publication
Publication Type
Journal
Abbreviation
Cell Death Differ.
Title
Cell Death and Differentiation
Publication Year
1994-
ISBN/ISSN
1350-9047
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