Reference Report

Reference
Citation	Lee, J.H., Koh, H., Kim, M., Park, J., Lee, S.Y., Lee, S., Chung, J. (2006). JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila. Cell Death Differ. 13(7): 1110--1122. (Export to RIS)
FlyBase ID	FBrf0194576
Publication Type	Research paper
PubMed ID	16273080
PubMed Abstract	Although recent progresses have unveiled the diverse in vivo functions of LKB1, detailed molecular mechanisms governing these processes still remain enigmatic. Here, we showed that Drosophila LKB1 negatively regulates organ growth by caspase-dependent apoptosis, without affecting cell size and cell cycle progression. Through genetic screening for LKB1 modifiers, we discovered the JNK pathway as a novel component of LKB1 signaling; the JNK pathway was activated by LKB1 and mediated the LKB1-dependent apoptosis. Consistently, LKB1-null mutant was defective in embryonic apoptosis and displayed a drastic hyperplasia in the central nervous system; these phenotypes were fully rescued by ectopic JNK activation as well as wild-type LKB1 expression. Furthermore, inhibition of LKB1 resulted in epithelial morphogenesis failure, which was associated with a decrease in JNK activity. Collectively, our studies unprecedentedly elucidate JNK as the downstream mediator of the LKB1-dependent apoptosis, and provide a new paradigm for understanding the diverse LKB1 functions in vivo.
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Secondary IDs	FBrf0189947
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Cell Death Differ.
Title	Cell Death and Differentiation
Publication Year	1994-
ISBN/ISSN	1350-9047
Data from Reference
Aberrations (1)
	Df(3L)H99
Alleles (31)
	Avic\GFP^{S65T.Scer\UAS} bsk¹ bsk² bsk^{K53R.Scer\UAS} bsk^Scer\UAS.cBa Ecol\lacZ^dpp.BS3.0 Ecol\lacZ^puc-E69 egr^Scer\UAS.cla gig^Scer\UAS.cTa hep^Act.Scer\UAS hep^r75 lkb1^4A4-2 lkb1^{dsRNA.Scer\UAS} lkb1^EP-1 lkb1^{K201I.Scer\UAS} lkb1^Scer\UAS.cLa lkb1^X5 msn^Scer\UAS.cSa p53^Ct.GUS puc^E69 puc^Scer\UAS.cMa rpr^Scer\UAS.C Scer\GAL4^ap-md544 Scer\GAL4^Bx-MS1096 Scer\GAL4^GMR.PF Scer\GAL4^hs.PB Scer\GAL4^pnr-MD237 Scer\GAL4^{Scer\FRT.Act5C} th^Scer\UAS.cHa Tsc1^Scer\UAS.cTa W^GMR.PG
Constructs (20)
	P{AyGAL4} P{BS3.0} P{GAL4-Hsp70.PB} P{GAL4-ninaE.GMR} P{GMR-hid} P{GUS-p53.Ct} P{UAS-bsk.B} P{UAS-bsk.K53R} P{UAS-DIAP1.H} P{UAS-egr.L} P{UAS-GFP.S65T} P{UAS-gig.T} P{UAS-Hep.Act} P{UAS-LKB1.IR} P{UAS-lkb1.K201I} P{UAS-lkb1.L} P{UAS-msn.S} P{UAS-puc.M} P{UAS-rpr.C} P{UAS-Tsc1.T}
Genes (19)
	Avic\GFP bsk Ecol\lacZ egr elav gig grim hep His3 Ice lkb1 msn p53 puc rpr Scer\GAL4 th Tsc1 W
Insertions (4)
	P{A92}puc^E69 P{GawB}ap^md544 P{GawB}Bx^MS1096 P{GawB}pnr^MD237