Reference Report

Reference
Citation	Kobayashi, M., Michaut, L., Ino, A., Honjo, K., Nakajima, T., Maruyama, Y., Mochizuki, H., Ando, M., Ghangrekar, I., Takahashi, K., Saigo, K., Ueda, R., Gehring, W.J., Furukubo-Tokunaga, K. (2006). Differential microarray analysis of Drosophila mushroom body transcripts using chemical ablation. Proc. Natl. Acad. Sci. U.S.A. 103(39): 14417--14422. (Export to RIS)
FlyBase ID	FBrf0194633
Publication Type	Research paper
PubMed ID	16971484
PubMed Abstract	Mushroom bodies (MBs) are the centers for olfactory associative learning and elementary cognitive functions in the Drosophila brain. As a way to systematically elucidate genes preferentially expressed in MBs, we have analyzed genome-wide alterations in transcript profiles associated with MB ablation by hydroxyurea. We selected 100 genes based on microarray data and examined their expression patterns in the brain by in situ hybridization. Seventy genes were found to be expressed in the posterodorsal cortex, which harbors the MB cell bodies. These genes encode proteins of diverse functions, including transcription, signaling, cell adhesion, channels, and transporters. Moreover, we have examined developmental functions of 40 of the microarray-identified genes by transgenic RNA interference; 8 genes were found to cause mild-to-strong MB defects when suppressed with a MB-Gal4 driver. These results provide important information not only on the repertoire of genes that control MB development but also on the repertoire of neural factors that may have important physiological functions in MB plasticity.
DOI	10.1073/pnas.0606571103
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Proc. Natl. Acad. Sci. U.S.A.
Title	Proceedings of the National Academy of Sciences of the United States of America
Publication Year	1915-
ISBN/ISSN	0027-8424
Data from Reference
Alleles (10)
	CG4853^{dsRNA.Scer\UAS} CG6083^{dsRNA.Scer\UAS} CG12301^{dsRNA.Scer\UAS} CG17221^{dsRNA.Scer\UAS} Hr46^{dsRNA.Scer\UAS} Itp-r83A^{dsRNA.Scer\UAS} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} PrBP^{dsRNA.Scer\UAS} Scer\GAL4^ey-OK107 S-Lap1^{dsRNA.Scer\UAS}
Constructs (9)
	P{UAS-CG4853-RNAi} P{UAS-CG6083-RNAi} P{UAS-CG6372-RNAi} P{UAS-CG9296-RNAi} P{UAS-CG12301-RNAi} P{UAS-CG17221-RNAi} P{UAS-Hr46-RNAi} P{UAS-Itp-r83A-RNAi} P{UAS-mCD8::GFP.L}
Genes (30)
	Brf CG4853 CG6083 CG8412 CG10205 CG10948 CG12301 CG14446 CG17221 CG44098 Dp1 ebd1 ey fbl6 fkh Hr46 Itp-r83A jing Mmus\Cd8a mod(mdg4) Nep1 Pkn PP2A-B' PrBP Scer\GAL4 S-Lap1 Spps tra2 trio usp
Insertions (1)
	P{GawB}ey^OK107
Natural transposons (1)
	P-element
Transcripts (1)
	Scer\GAL4^ey-OK107RA