Reference Report

Reference
Citation	Pepple, K.L., Anderson, A.E., Frankfort, B.J., Mardon, G. (2007). A genetic screen in Drosophila for genes interacting with senseless during neuronal development identifies the importin moleskin. Genetics 175(1): 125--141. (Export to RIS)
FlyBase ID	FBrf0194654
Publication Type	Research paper
PubMed ID	17110483
PubMed Abstract	Senseless (Sens) is a conserved transcription factor required for normal development of the Drosophila peripheral nervous system. In the Drosophila retina, sens is necessary and sufficient for differentiation of R8 photoreceptors and interommatidial bristles (IOBs). When Sens is expressed in undifferentiated cells posterior to the morphogenetic furrow, ectopic IOBs are formed. This phenotype was used to identify new members of the sens pathway in a dominant modifier screen. Seven suppressor and three enhancer complementation groups were isolated. Three groups from the screen are the known genes Delta, lilliputian, and moleskin/DIM-7 (msk), while the remaining seven groups represent novel genes with previously undefined functions in neural development. The nuclear import gene msk was identified as a potent suppressor of the ectopic interommatidial bristle phenotype. In addition, msk mutant adult eyes are extremely disrupted with defects in multiple cell types. Reminiscent of the sens mutant phenotype, msk eyes demonstrate reductions in the number of R8 photoreceptors due to an R8 to R2,5 fate switch, providing genetic evidence that Msk is a component of the sens pathway. Interestingly, in msk tissue, the loss of R8 fate occurs earlier than with sens and suggests a previously unidentified stage of R8 development between atonal and sens.
DOI	10.1534/genetics.106.065680
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (13)
	Df(1)sc10-1 Df(2L)C144 Df(2L)r10 Df(2R)59AD Df(2R)cn9 Df(2R)nap9 Df(3L)81k19 Df(3L)brm11 Df(3L)pbl-X1 Df(3R)by416 Df(3R)D605 Df(3R)Dl-BX12 In(2R)bw^VDe2LCy^R
Alleles (28)
	Caf1^unspecified Dl^9P Dl^B2 Dl^EFC6 Dl^EMH1 Dl^Scer\UAS.cUa E(ls)1¹ E(ls)3^unspecified Ecol\lacZ^rho-BB02 Ecol\lacZ^rM104 Ecol\lacZ^sca-rI234 Hrs^Scer\UAS.cLa lilli⁰⁰⁶³² lilli^unspecified msk⁴ msk⁵ msk^Scer\UAS.cLa msk^SFH2 msk^unspecified ro^Scer\UAS.cFa S(ls)1^unspecified S(ls)5^unspecified S(ls)6¹ S(ls)7^unspecified Scer\GAL4^bbg-C96 Scer\GAL4^ey.PH Scer\GAL4^lz-gal4 sens^Scer\UAS.cNa
Constructs (7)
	P{GAL4-ey.H} P{SUPor-P} P{UAS-Dl.U} P{UAS-Hrs.L} P{UAS-msk.L} P{UAS-ro.F} P{UAS-sens.N}
Genes (19)
	arm Caf1 Dl E(ls)1 E(ls)3 Ecol\lacZ elav Hrs lilli msk rho ro S(ls)1 S(ls)5 S(ls)6 S(ls)7 sca Scer\GAL4 sens
Insertions (13)
	P{A92}rho^BB02 P{EPgy2}sra^EY07182 P{GawB}bbg^C96 P{GawB}lz^gal4 P{lacZ}rM104 P{PZ}sca^rI234 P{SUPor-P}CG6904^KG00038 P{SUPor-P}DhpD^KG04159 P{SUPor-P}KG00569 P{SUPor-P}KG03062 P{SUPor-P}KG03264 P{SUPor-P}KG05698 P{SUPor-P}l(2)gl^KG05323
Natural transposons (1)
	P-element