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| Citation | Roberti, M., Bruni, F., Loguercio Polosa, P., Manzari, C., Gadaleta, M.N., Cantatore, P. (2006). MTERF3, the most conserved member of the mTERF-family, is a modular factor involved in mitochondrial protein synthesis. Biochim. Biophys. Acta 1757(9-10): 1199--1206. (Export to RIS) | ||
| FlyBase ID | FBrf0194696 | ||
| Publication Type | Research paper | ||
| PubMed ID | 16787637 | ||
| PubMed Abstract | The MTERF-family is a wide family of proteins identified in Metazoa and plants which includes the known mitochondrial transcription termination factors. With the aim to shed light on the function of MTERF-family members in Drosophila, we performed the cloning and characterization of D-MTERF3, a component of the most conserved group of this family. D-MTERF3 is a mitochondrial protein of 323 amino acids. Sequence analysis in seven different organisms showed that the protein contains five conserved "mTERF-motifs", three of which include a leucine zipper-like domain. D-MTERF3 knock-down, obtained by RNAi in D.Mel-2 cells, did not affect mitochondrial replication and transcription. On the contrary, it decreased to a variable extent the rate of labelling of about half of the mitochondrial polypeptides, with ND1 being the most affected by D-MTERF3 depletion. These results indicate that D-MTERF3 is involved in mitochondrial translation. This role, likely based on protein-protein interactions, may be exerted either through a direct interaction with the translation machinery or by bridging the mitochondrial transcription and translation apparatus. | ||
| DOI | 10.1016/j.bbabio.2006.04.026 | ||
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| Language of Publication | English | ||
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| Publication Type | Journal | ||
| Abbreviation | Biochim. Biophys. Acta | ||
| Title | Biochimica et Biophysica Acta | ||
| Publication Year | 1947- | ||
| ISBN/ISSN | 0006-3002 | ||
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Data from Reference
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| Genes (16)
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