Reference Report

Reference
Citation	Liu, Y., Lehmann, M. (2006). FOXO-independent suppression of programmed cell death by the PI3K/Akt signaling pathway in Drosophila. Dev. Genes Evol. 216(9): 531--535. (Export to RIS)
FlyBase ID	FBrf0194781
Publication Type	Research paper
PubMed ID	16520939
PubMed Abstract	Signaling through the PI3K/Akt/FOXO pathway plays an important role in vertebrates in protecting cells from programmed cell death. PI3K and Akt have been similarly shown to be involved in survival signaling in the invertebrate model organism Drosophila. However, it is not known whether PI3K and Akt execute this function by controlling a pro-apoptotic activity of Drosophila FOXO. In this study, we show that elevated signaling through PI3K and Akt can prevent developmentally controlled death in the salivary glands of the fruit fly. We further show that Drosophila FOXO is not required for normal salivary gland death and that the rescue of salivary gland death by PI3K occurs independent of FOXO. These results give support to the notion that FOXOs have acquired pro-apoptotic functions after separation of the vertebrate and invertebrate lineages.
DOI	10.1007/s00427-006-0063-x
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Genes Evol.
Title	Development genes and evolution
Publication Year	1996-
ISBN/ISSN	0949-944X
Data from Reference
Alleles (6)
	Akt1¹ Akt1^Scer\UAS.cSa Akt1^{Scer\UAS.T:Ivir\HA1,T:Uuuu\MyrPalm1} foxo²⁵ Pi3K92E^{Scer\UAS.T:Hsap\MYC} Scer\GAL4^hs.PB
Constructs (4)
	P{GAL4-Hsp70.PB} P{UAS-Akt1.S} P{UAS-myr-Akt1.S} P{WT-Dp110}
Genes (6)
	Akt1 foxo Pi3K92E rpr Scer\GAL4 W