Reference Report

Reference
Citation	Billeter, J.C., Villella, A., Allendorfer, J.B., Dornan, A.J., Richardson, M., Gailey, D.A., Goodwin, S.F. (2006). Isoform-specific control of male neuronal differentiation and behavior in Drosophila by the fruitless gene. Curr. Biol. 16(11): 1063--1076. (Export to RIS)
FlyBase ID	FBrf0194977
Publication Type	Research paper
PubMed ID	16753560
PubMed Abstract	How the central nervous system (CNS) develops to implement innate behaviors remains largely unknown. Drosophila male sexual behavior has long been used as a model to address this question. The male-specific products of fruitless (fru) are pivotal to the emergence of this behavior. These putative transcription factors, containing one of three alternative DNA binding domains, determine the neuronal substrates for sexual behavior in male CNS.We isolated the first fru coding mutation, resulting in complete loss of one isoform. At the neuronal level, this isoform alone controls differentiation of a male-specific muscle and its associated motorneuron. Conversely, a combination of isoforms is required for development of serotonergic neurons implicated in male copulatory behavior. Full development of these neurons requires the male-specific product of doublesex, a gene previously thought to act independently of fru. At the behavioral level, missing one isoform leads to diminished courtship behavior and infertility. We achieved the first rescue of a distinct fru behavioral phenotype, expressing a wild-type isoform in a defined subset of its normal expression pattern.This study exemplifies how complex behaviors can be controlled by a single locus through multiple isoforms regulating both developmental and physiological pathways in different neuronal substrates.
DOI	10.1016/j.cub.2006.04.039
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Aberrations (5)
	Df(3L)st-j7 Df(3R)dsx15 Df(3R)fru^4-40 Df(3R)fru^sat15 Df(3R)fru^w24
Alleles (12)
	Agam\fru^MC.Scer\UAS dsx²³ fru³ fru^4-40 fru^{MA.Scer\UAS.cSa} fru^{MB.Scer\UAS.cSa} fru^{MC.Scer\UAS.cSa} fru^sat15 fru^ΔC Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^fru.16 tra¹
Constructs (6)
	P{fru-GAL4.16} P{UAS-Agam\fru.MC} P{UAS-fru.MA.S} P{UAS-fru.MB.S} P{UAS-fru.MC.S} P{UAS-mCD8::GFP.L}
Genes (7)
	Agam\fru dsx fru futsch Mmus\Cd8a Scer\GAL4 tra
Natural transposons (1)
	P-element