Reference Report

Reference
Citation	Sato, A., Tomlinson, A. (2007). Dorsal-ventral midline signaling in the developing Drosophila eye. Development 134(4): 659--667. (Export to RIS)
FlyBase ID	FBrf0195057
Publication Type	Research paper
PubMed ID	17215299
PubMed Abstract	Boundaries between different cell types play key roles in many developmental patterning processes. They can be established by various mechanisms, and signaling between the different cell types can occur in a number of ways. One mechanism of crossboundary signaling is controlled by the Notch (N)-modifying protein Fringe (Fng). At the Drosophila wing dorsal-ventral (D-V) border, the mechanism by which an Fng(+)-Fng(-) interface controls local N activation has been well characterized. A similar N-activating Fng(+)-Fng(-) interface has also been described at the D-V border of the fly eye, but the mechanisms that establish and regulate it are different from those in the wing. Here we describe the ventral role of the Sloppy-paired (Slp) transcription factor, and its interactions with dorsally expressed Iroquois (Iro) transcription factors in the regulation of signaling about the Fng(+)-Fng(-) interface in the developing eye. The two transcription factors are mutually repressive and initially abut at the D-V midline. However, N signaling at the interface downregulates Slp expression, and a gap opens between the two expression domains in which Serrate (Ser, an N ligand) is upregulated.
DOI	10.1242/dev.02786
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (3)
	Df(2L)slp^S37A Df(2L)slp-Δ34B Df(3L)iro-DFM3
Alleles (17)
	Avic\GFP^Scer\UAS.cUa BacA\p35^Scer\UAS.cHa Ecol\lacZ^mirr-P1 Ecol\lacZ^Scer\UAS.cUa Ecol\lacZ^slp1-05965 mirr^Scer\UAS.cMa N^{3.hs.T:Scer\GAL4,T:Hsim\VP16} N^{intra.GS.Scer\UAS} N^l1N-ts1 Scer\GAL4^{Scer\FRT.Gal80.αTub84B} Scer\GAL4^αTub84B.PC Scer\GAL80^αTub84B.PC slp1^Scer\UAS.cSa slp2^AVm slp2^S37A slp2^Scer\UAS.cRa w^slp2-AVm
Constructs (11)
	P{N⁺-GV.3} P{Scer\UAS(-FRT)slp1.S} P{UAS-GFP.U} P{UAS-lacZ.U} P{UAS-mirr.M} P{UAS-N.intra.GS} P{UAS-p35.H} P{UAS-slp2.R} P{UASunk} P{αTub84B(FRT.Gal80.y⁺)GAL4.C} P{αTub84B(-FRT)GAL4.C}
Genes (14)
	Avic\GFP BacA\p35 Dl Ecol\lacZ eyg fng mirr N Scer\GAL4 Scer\GAL80 Ser slp1 slp2 w
Insertions (3)
	P{lacW}mirr^P1 P{PZ}slp1⁰⁵⁹⁶⁵ P{UASunk}slp2^AVm
Natural transposons (1)
	P-element