Open Close
Reference
Citation
Hauser, F., Williamson, M., Cazzamali, G., Grimmelikhuijzen, C.J. (2006). Identifying neuropeptide and protein hormone receptors in Drosophila melanogaster by exploiting genomic data.  Brief. Funct. Genomic. Proteomic. 4(4): 321--330.
FlyBase ID
FBrf0195077
Publication Type
Review
Abstract
Most neuropeptide and protein hormone receptors belong to the large superfamily of G-protein-coupled receptors (GPCRs). These cell membrane proteins steer many important processes such as development, reproduction, homeostasis and behaviour when activated by their corresponding ligands. The first insect genome, that of the fruitfly Drosophila melanogaster, was sequenced in 2000, and about 200 GPCRs have been annnotated in this model insect. About 50 of these receptors were predicted to have neuropeptides or protein hormones as their ligands. Since 2000, the cDNAs of most of these candidate receptors have been cloned and for many receptors the endogenous ligand has been identified. In this review, we will give an update about the current knowledge of all Drosophila neuropeptide and protein hormone receptors, and discuss their phylogenetic relationships.
PubMed ID
PubMed Central ID
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Brief. Funct. Genomic. Proteomic.
    Title
    Briefings in Functional Genomics & Proteomics
    Publication Year
    2002-
    ISBN/ISSN
    1473-9550
    Data From Reference