Reference Report

Reference
Citation	Park, S.K., Mann, K.J., Lin, H., Starostina, E., Kolski-Andreaco, A., Pikielny, C.W. (2006). A Drosophila protein specific to pheromone-sensing gustatory hairs delays males' copulation attempts. Curr. Biol. 16(11): 1154--1159. (Export to RIS)
FlyBase ID	FBrf0195097
Publication Type	Research paper
PubMed ID	16753571
PubMed Abstract	In insects, increasing evidence suggests that small secreted pheromone binding proteins (PBPs) and odorant binding proteins (OBPs) are important for normal olfactory detection of airborne pheromones and odorants far from their source. In contrast, it is unknown whether extracellular ligand binding proteins participate in perception of less volatile chemicals, including many pheromones, that are detected by direct contact with chemosensory organs. CheB42a, a small Drosophila melanogaster protein unrelated to known PBPs or OBPs, is expressed and likely secreted in only a small subset of gustatory sensilla on males' front legs, the site of gustatory perception of contact pheromones. Here we show that CheB42a is expressed specifically in the sheath cells surrounding the taste neurons expressing Gr68a, a putative gustatory pheromone receptor for female cuticular hydrocarbons that stimulate male courtship. Surprisingly, however, CheB42a mutant males attempt to copulate with females earlier and more frequently than control males. Furthermore, CheB42a mutant males also attempt to copulate more frequently with other males that secrete female-specific cuticular hydrocarbon pheromones, but not with females lacking cuticular hydrocarbons. Together, these data indicate that CheB42a is required for a normal gustatory response to female cuticular hydrocarbon pheromones that modulate male courtship.
DOI	10.1016/j.cub.2006.04.028
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Curr. Biol.
Title	Current Biology
Publication Year	1991-
ISBN/ISSN	0960-9822
Data from Reference
Aberrations (1)
	Df(2R)Δ5-22
Alleles (11)
	Avic\GFP^Scer\UAS.cUa CheB42a^+tTg1 CheB42a^ATGmut.+tTg1 CheB42a^Δ5-22 CheB42a^Δ5-68 Scer\GAL4^CheB42a.PX Scer\GAL4^Gr68a.PB Scer\GAL4^hs.PB Scer\GAL4^Obp19d.PS Scer\GAL4^OK376 tra^Scer\UAS.cFa
Constructs (8)
	P{ATGmut.Tg1} P{CheB42a-GAL4.X} P{GAL4-Hsp70.PB} P{Gr68a-GAL4.B} P{Obp19d-GAL4.S} P{Tg1} P{UAS-GFP.U} P{UAS-tra.F}
Genes (7)
	Avic\GFP CheB42a futsch Gr68a Obp19d Scer\GAL4 tra
Insertions (1)
	P{GawB}OK376
Natural transposons (1)
	P-element
Transcripts (3)
	Scer\GAL4^CheB42a.PXRA Scer\GAL4^Gr68a.PBRA Scer\GAL4^Pbprp2.PSRA