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Citation
Thummel, C.S. (2007). To die or not to die -- a role for Fork head.  J. Cell Biol. 176(6): 737--739.
FlyBase ID
FBrf0195115
Publication Type
Note
Abstract

The precise determination of when and where cells undergo programmed cell death is critical for normal development and tissue homeostasis. Cao et al. (2007; see p. 843 of this issue) report that the Fork head (Fkh) transcription factor, which is essential for the early development and function of the larval salivary glands in Drosophila melanogaster, also contributes to its demise. These authors show that fkh expression in the salivary glands is normally lost at puparium formation, which is approximately 12 h before they undergo massive cell death triggered by the steroid hormone ecdysone, making room for their developing adult counterparts. The loss of Fkh eliminates its role in blocking cell death, allowing for subsequent ecdysone-induced reaper and head involution defective death activator expression and tissue destruction. This study provides new insights into the transcriptional regulation of programmed cell death and the mechanisms that underlie the precise spatial and temporal control of hormone responses during development.

PubMed ID
PubMed Central ID
PMC1976266 (PMC) (EuropePMC)
Related Publication(s)
Research paper

Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death.
Cao et al., 2007, J. Cell Biol. 176(6): 843--852 [FBrf0193919]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    J. Cell Biol.
    Title
    Journal of Cell Biology
    Publication Year
    1966-
    ISBN/ISSN
    0021-9525
    Data From Reference
    Aberrations (1)
    Genes (10)