Reference Report

Reference
Citation	Hyun, J., Becam, I., Yanicostas, C., Bohmann, D. (2006). Control of G2/M transition by Drosophila Fos. Mol. Cell. Biol. 26(22): 8293--8302. (Export to RIS)
FlyBase ID	FBrf0195157
Publication Type	Research paper
PubMed ID	16966382
PubMed Abstract	The transcription factors of the Fos family have long been associated with the control of cell proliferation, although the molecular and cellular mechanisms that mediate this function are poorly understood. We investigated the contributions of Fos to the cell cycle and cell growth control using Drosophila imaginal discs as a genetically accessible system. The RNA interference-mediated inhibition of Fos in proliferating cells of the wing and eye discs resulted in a specific defect in the G2-to-M-phase transition, while cell growth remained unimpaired, resulting in a marked reduction in organ size. Consistent with the conclusion that Fos is required for mitosis, we identified cyclin B as a direct transcriptional target of Fos in Drosophila melanogaster, with Fos binding to a region upstream of the cyclin B gene in vivo and cyclin B mRNA being specifically reduced under Fos loss-of-function conditions.
DOI	10.1128/MCB.02455-05
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Mol. Cell. Biol.
Title	Molecular and Cellular Biology
Publication Year	1981-
ISBN/ISSN	0270-7306
Data from Reference
Alleles (14)
	Avic\GFP^E.Scer\UAS BacA\p35^Scer\UAS.cHa kay^{dsRNA.Scer\UAS} kay^Scer\UAS.cHa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^ap-md544 Scer\GAL4^en-e16E Scer\GAL4^ey.PH Scer\GAL4^GMR.PF Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} Scer\GAL4^sd-SG29.1 Scer\GAL4^T80 sro¹ w^+mC
Constructs (8)
	P{GAL4-Act5C(FRT.CD2).P} P{GAL4-ey.H} P{GAL4-ninaE.GMR} P{UAS-EGFP} P{UAS-kay.H} P{UAS-kay.RNAi} P{UAS-mCD8::GFP.L} P{UAS-p35.H}
Genes (13)
	Avic\GFP BacA\p35 cdc2 CycB CycD CycE kay Mmus\Cd8a puc Scer\GAL4 sro stg w
Insertions (4)
	P{en2.4-GAL4}e16E P{GawB}ap^md544 P{GawB}sd^SG29.1 P{GawB}T80