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Citation
Edwards, A.C., Rollmann, S.M., Morgan, T.J., Mackay, T.F. (2006). Quantitative genomics of aggressive behavior in Drosophila melanogaster.  PLoS Genet. 2(9): e154.
FlyBase ID
FBrf0195262
Publication Type
Research paper
Abstract
Aggressive behavior is important for animal survival and reproduction, and excessive aggression is an enormous social and economic burden for human society. Although the role of biogenic amines in modulating aggressive behavior is well characterized, other genetic mechanisms affecting this complex behavior remain elusive. Here, we developed an assay to rapidly quantify aggressive behavior in Drosophila melanogaster, and generated replicate selection lines with divergent levels of aggression. The realized heritability of aggressive behavior was approximately 0.10, and the phenotypic response to selection specifically affected aggression. We used whole-genome expression analysis to identify 1,539 probe sets with different expression levels between the selection lines when pooled across replicates, at a false discovery rate of 0.001. We quantified the aggressive behavior of 19 mutations in candidate genes that were generated in a common co-isogenic background, and identified 15 novel genes affecting aggressive behavior. Expression profiling of genetically divergent lines is an effective strategy for identifying genes affecting complex traits.
PubMed ID
PubMed Central ID
PMC1564424 (PMC) (EuropePMC)
Related Publication(s)
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Microarray Normalization Protocol for Edwards et al.
Costello et al., 2008.9.10, Microarray Normalization Protocol for Edwards et al. [FBrf0205601]
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    PLoS Genet.
    Title
    PLoS Genetics
    Publication Year
    2005-
    ISBN/ISSN
    1553-7404 1553-7390
    Data From Reference