Reference Report

Reference
Citation	Brodu, V., Casanova, J. (2006). The RhoGAP crossveinless-c links trachealess and EGFR signaling to cell shape remodeling in Drosophila tracheal invagination. Genes Dev. 20(13): 1817--1828. (Export to RIS)
FlyBase ID	FBrf0195282
Publication Type	Research paper
PubMed ID	16818611
PubMed Abstract	A major issue in morphogenesis is to understand how the activity of genes specifying cell fate affects cytoskeletal components that modify cell shape and induce cell movements. Here, we approach this question by investigating how a group of cells from an epithelial sheet initiate invagination to ultimately form the Drosophila tracheal tubes. We describe tracheal cell behavior at invagination and show that it is associated with, and requires, a distinct recruitment of Myosin II to the apical surface of cells at the invaginating edge. We show that this process is achieved by the activity of crossveinless-c, a gene coding for a RhoGAP and whose specific transcriptional activation in the tracheal cells is triggered by both the trachealess patterning gene and the EGF Receptor (EGFR) signaling pathway. Our results identify a developmental pathway linking cell fate genes and cell signaling pathways to intracellular modifications during tracheal cell invagination.
DOI	10.1101/gad.375706
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (1)
	Df(2L)32FP-5
Alleles (20)
	btl^LG19 cv-c⁷ cv-c^M62 cv-c^Scer\UAS.cDa Egfr^f2 Mtl^Δ Rac2^Δ Rho1^72R Rho1^E3.10 rho^7M43 rho^{Scer\UAS.cdCa} salm^32FP-5 Scer\GAL4^69B Scer\GAL4^ptc-559.1 Scer\GAL4^salm-459.2 spi² sqh^{RLC.T:Avic\GFP-S65T} trh¹ zip¹ zip^{ΔHD.Scer\UAS.T:Avic\GFP-YFP}
Constructs (4)
	P{sqh-GFP.RLC} P{UAS-cv-c.D} P{UAS-ve.dC} P{UAS-zip-DN.GFP-YFP}
Genes (19)
	Act5C Act42A btl cv-c Egfr inaC Mtl Nrt Rac2 rho Rho1 rl salm Scer\GAL4 spi sqh trh zip α-Spec
Insertions (3)
	P{GawB}69B P{GawB}459.2 P{GawB}ptc^559.1