Reference Report

Reference
Citation	Krattinger, A., Gendre, N., Ramaekers, A., Grillenzoni, N., Stocker, R.F. (2007). DmOAZ, the unique Drosophila melanogaster OAZ homologue is involved in posterior spiracle development. Dev. Genes Evol. 217(3): 197--208. (Export to RIS)
FlyBase ID	FBrf0195312
Publication Type	Research paper
PubMed ID	17323106
PubMed Abstract	In this paper, we study DmOAZ, the unique Drosophila melanogaster homologue of the OAZ zinc finger protein family. We show partial conservation of the zinc finger organization between DmOAZ and the vertebrate members of this family. We determine the exon/intron structure of the dmOAZ gene and deduce its open reading frame. Reverse transcriptase-polymerase chain reaction analysis shows that dmOAZ is transcribed throughout life. In the embryo, strongest DmOAZ expression is observed in the posterior spiracles. We suggest that dmOAZ acts as a secondary target of the Abd-B gene in posterior spiracle development, downstream of cut and ems. In a newly created loss-of-function mutant, dmOAZ ( 93 ), the "filzkörper" part of the posterior spiracles, is indeed structurally abnormal. The dmOAZ ( 93 ) mutant is a larval lethal, a phenotype that may be linked to the spiracular defect. Given the dmOAZ ( 93 ) mutant as a new tool, the fruit fly may provide an alternative model for analyzing in vivo the functions of OAZ family members.
DOI	10.1007/s00427-007-0134-7
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Dev. Genes Evol.
Title	Development genes and evolution
Publication Year	1996-
ISBN/ISSN	0949-944X
Data from Reference
Aberrations (4)
	Df(2L)32FP-5 Df(2L)GR4 Df(2R)en^E Df(2R)L48
Alleles (12)
	Abd-B^M1 Avic\GFP^Scer\UAS.cUa ct^db7 Ecol\lacZ^ct.D Ecol\lacZ^ems.1.2 Ecol\lacZ^grh.NB ems² grh^B32 Oaz⁹³ salm² Scer\GAL4^ems.HRE trh⁸
Constructs (5)
	P{cutD-hsp70-lacZ} P{ems-GAL4.HRE} P{ems-lacZ.1.2} P{grh-lacZ.NB} P{UAS-GFP.U}
Genes (10)
	Abd-B Avic\GFP ct Ecol\lacZ ems grh Oaz salm Scer\GAL4 trh
Insertions (1)
	P{GawB}GH146