Reference Report

Reference
Citation	Wang, T., Jiao, Y., Montell, C. (2007). Dissection of the pathway required for generation of vitamin A and for Drosophila phototransduction. J. Cell Biol. 177(2): 305--316. (Export to RIS)
FlyBase ID	FBrf0199300
Publication Type	Research paper
PubMed ID	17452532
PubMed Abstract	Dietary carotenoids are precursors for the production of retinoids, which participate in many essential processes, including the formation of the photopigment rhodopsin. Despite the importance of conversion of carotenoids to vitamin A (all-trans-retinol), many questions remain concerning the mechanisms that promote this process, including the uptake of carotenoids. We use the Drosophila visual system as a genetic model to study retinoid formation from beta-carotene. In a screen for mutations that affect the biosynthesis of rhodopsin, we identified a class B scavenger receptor, SANTA MARIA. We demonstrate that SANTA MARIA functions upstream of vitamin A formation in neurons and glia, which are outside of the retina. The protein is coexpressed and functionally coupled with the beta, beta-carotene-15, 15'-monooxygenase, NINAB, which converts beta-carotene to all-trans-retinal. Another class B scavenger receptor, NINAD, functions upstream of SANTA MARIA in the uptake of carotenoids, enabling us to propose a pathway involving multiple extraretinal cell types and proteins essential for the formation of rhodopsin.
DOI	10.1083/jcb.200610081
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	J. Cell Biol.
Title	Journal of Cell Biology
Publication Year	1966-
ISBN/ISSN	0021-9525
Data from Reference
Aberrations (2)
	Df(2L)ED479 Df(2L)Exel7031
Alleles (20)
	Avic\GFP^{Scer\UAS.T:SV40\nls2} Hsap\SCARB1^Scer\UAS.cWa ninaB¹ ninaB^Scer\UAS.cGa ninaD² ninaD^Scer\UAS.cKa ninaE⁶ santa-maria¹ santa-maria^hs.PW santa-maria^Scer\UAS.cWa Scer\GAL4^drm.7.1 Scer\GAL4^elav.PLu Scer\GAL4^GMR.PF Scer\GAL4^ninaB.PW Scer\GAL4^ninaD.PW Scer\GAL4^ninaE.PD Scer\GAL4^rdhB.PW Scer\GAL4^repo Scer\GAL4^{santa-maria.PW} w^+mC
Constructs (14)
	P{drm-GAL4.7.1} P{GAL4-elav.L} P{GAL4-ninaE.GMR} P{hs-santa-maria.W} P{ninaB-GAL4.W} P{ninaD-GAL4.W} P{ninaE-GAL4.D} P{rdhB-GAL4.W} P{santa-maria-GAL4.W} P{UAS-GFP.nls} P{UAS-ninaB.G} P{UAS-ninaD} P{UAS-santa-maria.W} P{UAS-SR-BI.W}
Genes (14)
	Avic\GFP CG5958 CG5973 elav Hsap\SCARB1 ninaB ninaD ninaE norpA repo Rh4 santa-maria Scer\GAL4 w
Insertions (1)
	P{GAL4}repo
Natural transposons (1)
	P-element