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Citation
Langille, M.G.I., Clark, D.V. (2007). Parent genes of retrotransposition-generated gene duplicates in Drosophila melanogaster have distinct expression profiles.  Genomics 90(3): 334--343.
FlyBase ID
FBrf0200094
Publication Type
Research paper
Abstract

Genes arising by retrotransposition are always different from their parent genes from the outset. In addition, the cDNA must insert into a region that allows expression or it will become a processed pseudogene. We sought to determine whether this class of gene duplication differs from other gene duplications based on functional criteria. Using amino acid sequences from Drosophila melanogaster, we identified retroduplicated gene pairs at various levels of sequence identity. Analysis of gene ontology annotations showed some enrichment of retroduplications in the cellular physiological processes class. Retroduplications show a higher level of nucleotide substitution than other gene duplications, suggesting a higher rate of divergence. Remarkably, analysis of microarray data for gene expression during embryogenesis showed that parent genes are more highly expressed relative to their retroduplicated copies, tandem duplications, and all genes. Furthermore, an expressed sequence tag library representation shows a broader distribution for parent genes than for all other genes and, as found previously by others, retroduplicated gene transcripts are found most abundantly in testes. Therefore, in examining retroduplicated gene pairs, we have found that parent genes of retroduplications are also a distinctive class in terms of transcript expression levels and distribution.

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PubMed Central ID
Related Publication(s)
FlyBase analysis

Summary of published retrogene analyses.
dos Santos, 2014, Summary of published retrogene analyses. [FBrf0225799]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Genomics
    Title
    Genomics
    Publication Year
    1987-
    ISBN/ISSN
    0888-7543
    Data From Reference