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Reference
Citation	Grewal, S.I.S., Elgin, S.C.R. (2007). Transcription and RNA interference in the formation of heterochromatin. Nature 447(7143): 399--406.
FlyBase ID	FBrf0200338
Type of publication	Review
Offprint Available	No
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PubMed ID	17522672
PubMed Abstract	Transcription in heterochromatin seems to be an oxymoron--surely the 'silenced' form of chromatin should not be transcribed. But there have been frequent reports of low-level transcription in heterochromatic regions, and several hundred genes are found in these regions in Drosophila. Most strikingly, recent investigations implicate RNA interference mechanisms in targeting and maintaining heterochromatin, and these mechanisms are inherently dependent on transcription. Silencing of chromatin might involve trans-acting sources of the crucial small RNAs that carry out RNA interference, but in some cases, transcription of the region to be silenced seems to be required--an apparent contradiction.
Biosis	2007.424729
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Language of publication	English
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Abbreviation	Nature
Title	Nature
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Volume range	1-
Year range	1869-
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Place of publication	London
Language of publication	English
ISBN/ISSN	0028-0836
CODEN	NATUAS
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Genes (22)
	AGO1 AGO2 AGO3 D1 Dcr-2 E(z) Hcf His3 His4 JIL-1 Rpd3 Ste Su(Ste) Su(var)2-HP2 Su(var)205 Su(var)3-7 Su(var)3-9 Suv4-20 aub cid piwi w
Natural transposons (1)
	1360