Reference Report

Reference
Citation	Pal, S., Leger, R.J.S., Wu, L.P. (2007). Fungal peptide destruxin a plays a specific role in suppressing the innate immune response in Drosophila melanogaster. J. Biol. Chem. 282(12): 8969--8977. (Export to RIS)
FlyBase ID	FBrf0200357
Publication Type	Research paper
PubMed ID	17227774
PubMed Abstract	Destruxins are a class of insecticidal, anti-viral, and phytotoxic cyclic depsipeptides that are also studied for their toxicity to cancer cells. They are produced by various fungi, and a direct relationship has been established between Destruxin production and the virulence of the entomopathogen Metarhizium anisopliae. Aside from opening calcium channels, their in vivo mode of action during pathogenesis remains largely uncharacterized. To better understand the effects of a Destruxin, we looked at changes in gene expression following injection of Destruxin A into the fruit fly Drosophila melanogaster. Microarray results revealed reduced expression of various antimicrobial peptides that play a major role in the humoral immune response of the fly. Flies co-injected with a non-lethal dose of Destruxin A and the normally innocuous Gram-negative bacteria Escherichia coli, showed increased mortality and an accompanying increase in bacterial titers. Mortality due to sepsis was rescued through ectopic activation of components in the IMD pathway, one of two signal transduction pathways that are responsible for antimicrobial peptide induction. These results demonstrate a novel role for Destruxin A in specific suppression of the humoral immune response in insects.
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Secondary IDs	FBrf0193030
Language of Publication	English
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Publication Type	Journal
Abbreviation	J. Biol. Chem.
Title	Journal of Biological Chemistry
Publication Year	1905-
ISBN/ISSN	0021-9258
Data from Reference
Alleles (6)
	Dpt^Scer\UAS.cTa Drs^Scer\UAS.cTa imd^Scer\UAS.cGa ird5^Scer\UAS.cLa PGRP-SA^Scer\UAS.cMa Scer\GAL4^c564
Constructs (5)
	P{UAS-Dpt.T} P{UAS-Drs.T} P{UAS-imd.G} P{UAS-ird5.L} P{UAS-PGRP-SA.N}
Genes (69)
	AttC AttD CecA1 CecA2 CecB CecC CG3604 CG3838 CG4096 CG5909 CG6675 CG9568 CG9616 CG9733 CG9861 CG12780 CG12821 CG13323 CG13324 CG13422 CG13905 CG14073 CG14419 CG15068 CG15126 CG16713 CG16836 CG17738 CG42561 CG42562 CG44325 crq Dpt Drat Dro Drs GNBP2 GNBP3 grim Hayan Hsp23 Hsp27 Hsp70Bc Ice IM3 imd ird5 lectin-22C Mtk nec PGRP-LB PGRP-LC PGRP-LF PGRP-SA PGRP-SB1 PGRP-SC2 PGRP-SD pll rpr Scer\GAL4 Socs36E SPE Spn31A Spn42Dc Spn43Aa Spn43Ad Tep4 Thor Tl
Insertions (1)
	P{GawB}c564