Reference Report

Reference
Citation	Kurtovic, A., Widmer, A., Dickson, B.J. (2007). A single class of olfactory neurons mediates behavioural responses to a Drosophila sex pheromone. Nature 446(7135): 542--546. (Export to RIS)
FlyBase ID	FBrf0200390
Publication Type	Research paper
PubMed ID	17392786
PubMed Abstract	Insects, like many other animals, use sex pheromones to coordinate their reproductive behaviours. Volatile pheromones are detected by odorant receptors expressed in olfactory receptor neurons (ORNs). Whereas fruit odours typically activate multiple ORN classes, pheromones are thought to act through single dedicated classes of ORN. This model predicts that activation of such an ORN class should be sufficient to trigger the appropriate behavioural response. Here we show that the Drosophila melanogaster male-specific pheromone 11-cis-vaccenyl acetate (cVA) acts through the receptor Or67d to regulate both male and female mating behaviour. Mutant males that lack Or67d inappropriately court other males, whereas mutant females are less receptive to courting males. These data suggest that cVA has opposite effects in the two sexes: inhibiting mating behaviour in males but promoting mating behaviour in females. Replacing Or67d with moth pheromone receptors renders these ORNs sensitive to the corresponding moth pheromones. In such flies, moth pheromones elicit behavioural responses that mimic the normal response to cVA. Thus, activation of a single ORN class is both necessary and sufficient to mediate behavioural responses to the Drosophila sex pheromone cVA.
DOI	10.1038/nature05672
Related Publication(s)
Supplementary material	Supplementary information. [FBrf0200334]
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Secondary IDs
Language of Publication	English
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Publication Type	Journal
Abbreviation	Nature
Title	Nature
Publication Year	1869-
ISBN/ISSN	0028-0836
Data from Reference
Alleles (10)
	Bmor\OR-1^Scer\UAS.cKa Hvir\HR13^Scer\UAS.cKa Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Or67d⁺¹ Or67d⁺² Or67d^GAL4-1 Or67d^GAL4-2 Or67d^Scer\UAS.cKa Scer\GAL4^Or67d-GAL4-1 Scer\GAL4^Or67d-GAL4-2
Constructs (4)
	P{UAS-BmOR1.K} P{UAS-HR13.K} P{UAS-mCD8::GFP.L} P{UAS-Or67d.K}
Genes (6)
	Bmor\OR-1 brp Hvir\HR13 Mmus\Cd8a Or67d Scer\GAL4
Insertions (2)
	P{UAS-Or67d.K}T1 P{UAS-Or67d.K}T2
Natural transposons (1)
	P-element