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Citation
Berry, D.L., Baehrecke, E.H. (2007). Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila.  Cell 131(6): 1137--1148.
FlyBase ID
FBrf0200408
Publication Type
Research paper
Abstract

Autophagy is a catabolic process that is negatively regulated by growth and has been implicated in cell death. We find that autophagy is induced following growth arrest and precedes developmental autophagic cell death of Drosophila salivary glands. Maintaining growth by expression of either activated Ras or positive regulators of the class I phosphoinositide 3-kinase (PI3K) pathway inhibits autophagy and blocks salivary gland cell degradation. Developmental degradation of salivary glands is also inhibited in autophagy gene (atg) mutants. Caspases are active in PI3K-expressing and atg mutant salivary glands, and combined inhibition of both autophagy and caspases increases suppression of gland degradation. Further, induction of autophagy is sufficient to induce premature cell death in a caspase-independent manner. Our results provide in vivo evidence that growth arrest, autophagy, and atg genes are required for physiological autophagic cell death and that multiple degradation pathways cooperate in the efficient clearance of cells during development.

PubMed ID
PubMed Central ID
PMC2180345 (PMC) (EuropePMC)
Related Publication(s)
Note

Autophagy and cell death: no longer at odds.
Bergmann, 2007, Cell 131(6): 1032--1034 [FBrf0201883]

Autophagy functions in programmed cell death.
Berry and Baehrecke, 2008, Autophagy 4(3): 359--360 [FBrf0204916]

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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Cell
    Title
    Cell
    Publication Year
    1974-
    ISBN/ISSN
    0092-8674
    Data From Reference