Reference Report

Reference
Citation	Schnorrer, F., Kalchhauser, I., Dickson, B.J. (2007). The transmembrane protein kon-tiki couples to Dgrip to mediate myotube targeting in Drosophila. Dev. Cell 12(5): 751--766. (Export to RIS)
FlyBase ID	FBrf0200480
Publication Type	Research paper
PubMed ID	17488626
PubMed Abstract	Directed cell migration and target recognition are critical for the development of both the nervous and muscular systems. Molecular mechanisms that control these processes in the nervous system have been intensively studied, whereas those that act during muscle development are still largely uncharacterized. Here we identify a transmembrane protein, Kon-tiki (Kon), that mediates myotube target recognition in the Drosophila embryo. Kon is expressed in a specific subset of myotubes and is required autonomously for these myotubes to recognize their tendon cell targets and to establish a stable connection. Kon is enriched at myotube tips during targeting and signals through the intracellular adaptor Dgrip in a conserved molecular pathway. Forced overexpression of Kon stimulates muscle motility. We propose that Kon promotes directed myotube migration and transduces a target-derived signal that initiates the formation of a stable connection.
DOI	10.1016/j.devcel.2007.02.017
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
ISBN/ISSN
Data from Reference
Aberrations (4)
	Df(2L)Exel6041 Df(2L)Exel8038 Df(2L)M36F-S5 Df(2L)TW137
Alleles (20)
	Grip^{dsRNA.Scer\UAS.cSa} Grip^ex36 kon^A04 kon^A49 kon^C25 kon^C41 kon^C452 kon^C1115 kon^C1139 kon^C2263 kon^{Scer\UAS.T:Ivir\HA1,T:SS-wg} kon^{VG.Scer\UAS.T:Ivir\HA1,T:SS-wg} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Mmus\Cd8a^{slou.T:Avic\GFP} Moe^{GMA.Scer\UAS.T:Avic\GFP-S65T} Scer\GAL4^Bx-MS1096 Scer\GAL4^Mef2.PR Scer\GAL4^sr-md710 Scer\GAL4^tey-5053A w^+mC
Constructs (7)
	P{GAL4-Mef2.R} P{slou-mCD8-GFP} P{UAS-GMA} P{UAS-Grip.IR} P{UAS-kon.HA.VG} P{UAS-kon.HA} P{UAS-mCD8::GFP.L}
Genes (16)
	CG10176 CG10178 CG10211 CG10283 Grip kon Mhc Mmus\Cd8a Moe Pde11 Scer\GAL4 T:Avic\GFP T:Ivir\HA1 T:SS-wg w βTub60D
Insertions (3)
	P{GawB}Bx^MS1096 P{GawB}sr^md710 P{GawB}tey^5053A
Natural transposons (1)
	P-element