Reference Report

Reference
Citation	Grönke, S., Müller, G., Hirsch, J., Fellert, S., Andreou, A., Haase, T., Jäckle, H., Kühnlein, R.P. (2007). Dual lipolytic control of body fat storage and mobilization in Drosophila. PLoS Biol. 5(6): e137. (Export to RIS)
FlyBase ID	FBrf0200542
Publication Type	Research paper
PubMed ID	17488184
PubMed Abstract	Energy homeostasis is a fundamental property of animal life, providing a genetically fixed balance between fat storage and mobilization. The importance of body fat regulation is emphasized by dysfunctions resulting in obesity and lipodystrophy in humans. Packaging of storage fat in intracellular lipid droplets, and the various molecules and mechanisms guiding storage-fat mobilization, are conserved between mammals and insects. We generated a Drosophila mutant lacking the receptor (AKHR) of the adipokinetic hormone signaling pathway, an insect lipolytic pathway related to ss-adrenergic signaling in mammals. Combined genetic, physiological, and biochemical analyses provide in vivo evidence that AKHR is as important for chronic accumulation and acute mobilization of storage fat as is the Brummer lipase, the homolog of mammalian adipose triglyceride lipase (ATGL). Simultaneous loss of Brummer and AKHR causes extreme obesity and blocks acute storage-fat mobilization in flies. Our data demonstrate that storage-fat mobilization in the fly is coordinated by two lipocatabolic systems, which are essential to adjust normal body fat content and ensure lifelong fat-storage homeostasis.
DOI	10.1371/journal.pbio.0050137
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Language of Publication	English
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Publication Type	Journal
Abbreviation	PLoS Biol.
Title	PLoS Biology
Publication Year	2003-
ISBN/ISSN	1545-7885 1544-9173
Data from Reference
Alleles (16)
	Akh^Scer\UAS.cLa AkhR¹ AkhR² AkhR^A1332 AkhR^G6244 AkhR^revA AkhR^revB AkhR^Scer\UAS.cGa bmm¹ bmm^rev bmm^Scer\UAS.cGa CG11188^A1332 rpr^Scer\UAS.cGa Scer\GAL4^Akh.PG Scer\GAL4^fat w^+mC
Constructs (8)
	P{?EP} P{Akh-gal4.G} P{EP} P{Mae-UAS.6.11} P{UAS-Akh.L} P{UAS-AKHR.G} P{UAS-bmm.cGa} P{UAS-rpr.G}
Genes (8)
	Adh Akh AkhR bmm CG11188 rpr Scer\GAL4 w
Insertions (5)
	P{?EP}AkhR¹ P{?EP}AkhR² P{EP}AkhR^G6244 P{GAL4}fat P{Mae-UAS.6.11}CG11188^A1332
Natural transposons (1)
	P-element