|Citation||Mehnert, K.I., Beramendi, A., Elghazali, F., Negro, P., Kyriacou, C.P., Cantera, R. (2007). Circadian changes in Drosophila motor terminals. Dev. Neurobiol. 67(4): 415--421. (Export to RIS)|
|Publication Type||Research paper|
|PubMed Abstract||In Drosophila melanogaster, as in most other higher organisms, a circadian clock controls the rhythmic distribution of rest/sleep and locomotor activity. Here we report that the morphology of Drosophila flight neuromuscular terminals changes between day and night, with a rhythm in synaptic bouton size that continues in constant darkness, but is abolished during aging. Furthermore, arrhythmic mutations in the clock genes timeless and period also disrupt this circadian rhythm. Finally, these clock mutants also have an opposing effect on the nonrhythmic phenotype of neuronal branching, with tim mutants showing a dramatic hyperbranching morphology and per mutants having fewer branches than wild-type flies. These unexpected results reveal further circadian as well as nonclock related pleiotropic effects for these classic behavioral mutants.|
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|Language of Publication||English|
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