Reference Report

Reference
Citation	Xue, L., Igaki, T., Kuranaga, E., Kanda, H., Miura, M., Xu, T. (2007). Tumor suppressor CYLD regulates JNK-Induced cell death in Drosophila. Dev. Cell 13(3): 446--454. (Export to RIS)
FlyBase ID	FBrf0200559
Publication Type	Research paper
PubMed ID	17765686
PubMed Abstract	CYLD encodes a tumor suppressor that is mutated in familial cylindromatosis. Despite biochemical and cell culture studies, the physiological functions of CYLD in animal development and tumorigenesis remain poorly understood. To address these questions, we generated Drosophila CYLD (dCYLD) mutant and transgenic flies expressing wild-type and mutant dCYLD proteins. Here we show that dCYLD is essential for JNK-dependent oxidative stress resistance and normal lifespan. Furthermore, dCYLD regulates TNF-induced JNK activation and cell death through dTRAF2, which acts downstream of the TNF receptor Wengen and upstream of the JNKK kinase dTAK1. We show that dCYLD encodes a deubiquitinating enzyme that deubiquitinates dTRAF2 and prevents dTRAF2 from ubiquitin-mediated proteolytic degradation. These data provide a molecular mechanism for the tumor suppressor function of this evolutionary conserved molecule by indicating that dCYLD plays a critical role in modulating TNF-JNK-mediated cell death.
DOI
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Dev. Cell
Title	Developmental Cell
Publication Year	2001-
ISBN/ISSN
Data from Reference
Aberrations (1)
	Df(2L)CYLD^mr4
Alleles (30)
	bsk¹ bsk^Scer\UAS.cBa CG13138^+tLX107 CYLD^mr4 CYLD^Scer\UAS.cXa CYLD^t5.9 CYLD^{ΔCAP.Scer\UAS} CYLD^{ΔUCH.Scer\UAS} CYLD^{ΔZF.Scer\UAS} Ecol\lacZ^puc-E69 egr^Scer\UAS.cIa hep¹ hep^NIG.4353R nmd⁰⁸⁷⁷⁴ nmd^+tLX107 nmd^mr4 Scer\GAL4^GMR.PF Scer\GAL4^hs.2sev Scer\GAL4^pnr-MD237 Scer\GAL4^tub.PU Tak1^NIG.1388R Tak1^Scer\UAS.cMa Traf4^{dsRNA.Scer\UAS} Traf4^ex1 Traf6^{dsRNA.Scer\UAS} Traf6^ex1 Traf6^{Scer\UAS.T:Zzzz\FLAG} w^+mC w^+mW.hs wgn^{dsRNA.Scer\UAS}
Constructs (18)
	P{CYLD.Res.5.9} P{GAL4-Hsp70.sev} P{GAL4-ninaE.GMR} P{LX107} P{NIG.1388R} P{NIG.4353R} P{tub-GAL4.U} P{UAS-bsk.B} P{UAS-CYLD.X} P{UAS-CYLD.ΔCAP} P{UAS-CYLD.ΔUCH} P{UAS-CYLD.ΔZF} P{UAS-eiger.I} P{UAS-FLAG-Traf2} P{UAS-Tak1.M} P{UAS-Traf1.IR} P{UAS-Traf6.IR} P{UAS-wengen-IR}
Genes (20)
	bsk CG5390 CG13138 CYLD Ecol\lacZ egr foxo Hand hep nmd puc Scer\GAL4 shark Src42A T:Zzzz\FLAG Tak1 Traf4 Traf6 w wgn
Insertions (3)
	P{A92}puc^E69 P{GawB}pnr^MD237 P{PZ}nmd⁰⁸⁷⁷⁴
Natural transposons (1)
	P-element