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Citation
Lemos, B., Araripe, L.O., Hartl, D.L. (2008). Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences.  Science 319(5859): 91--93.
FlyBase ID
FBrf0200757
Publication Type
Research paper
Abstract
The paucity of polymorphisms in single-copy genes on the Y chromosome of Drosophila contrasts with data indicating that this chromosome has polymorphic phenotypic effects on sex ratio, temperature sensitivity, behavior, and fitness. We show that the Y chromosome of D. melanogaster harbors substantial genetic diversity in the form of polymorphisms for genetic elements that differentially affect the expression of hundreds of X-linked and autosomal genes. The affected genes are more highly expressed in males, more meagerly expressed in females, and more highly divergent between species. Functionally, they affect microtubule stability, lipid and mitochondrial metabolism, and the thermal sensitivity of spermatogenesis. Our findings provide a mechanism for adaptive phenotypic variation associated with the Y chromosome.
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Related Publication(s)
Note
Genetics. Functionally degenerate--Y not so?
Rice and Friberg, 2008, Science 319(5859): 42--43 [FBrf0202861]
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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Science
    Title
    Science
    Publication Year
    1895-
    ISBN/ISSN
    0036-8075
    Data From Reference
    Genes (10)
    Natural transposons (4)