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Citation
Orian, A., Delrow, J.J., Nieves, A.E.R., Abed, M., Metzger, D., Paroush, Z., Eisenman, R.N., Parkhurst, S.M. (2007). A Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development.  Proc. Natl. Acad. Sci. U.S.A. 104(40): 15771--15776.
FlyBase ID
FBrf0200831
Publication Type
Research paper
Abstract

Integration of patterning cues via transcriptional networks to coordinate gene expression is critical during morphogenesis and misregulated in cancer. Using DNA adenine methyltransferase (Dam)ID chromatin profiling, we identified a protein-protein interaction between the Drosophila Myc oncogene and the Groucho corepressor that regulates a subset of direct dMyc targets. Most of these shared targets affect fate or mitosis particularly during neurogenesis, suggesting the dMyc-Groucho complex may coordinate fate acquisition with mitotic capacity during development. We find an antagonistic relationship between dMyc and Groucho that mimics the antagonistic interactions found for EGF and Notch signaling: dMyc is required to specify neuronal fate and enhance neuroblast mitosis, whereas Groucho is required to maintain epithelial fate and inhibit mitosis. Our results suggest that the dMyc-Groucho complex defines a previously undescribed mechanism of Myc function and may serve as the transcriptional unit that integrates EGF and Notch inputs to regulate early neuronal development.

PubMed ID
PubMed Central ID
PMC2000393 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Alleles (9)
    Genes (22)
    Physical Interactions (8)
    Natural transposons (1)
    Experimental Tools (1)
    Transgenic Constructs (3)