Reference Report

Reference
Citation	Cooper, S.E. (2007). In vivo function of a novel Siah protein in Drosophila. Mech. Dev. 124(7-8): 584--591. (Export to RIS)
FlyBase ID	FBrf0200839
Publication Type	Research paper
PubMed ID	17561381
PubMed Abstract	The Siah proteins, mammalian homologues of the Drosophila Sina protein, function as E3 ubiquitin ligase enzymes and target a wide range of cellular proteins for degradation. Here, I investigate the in vivo function of the fly protein, Sina-Homologue (SinaH), which is highly similar to Sina. Flies that completely lack SinaH are viable and in combination with a mutation in the gene, Ebi, show an extra dorsal central bristle phenotype. I also show that SinaH and Ebi can interact with each other both in vivo and in vitro suggesting that they act in the same physical complex. Flies that lack both Sina and Sina-Homologue were also created and show visible eye and bristle phenotypes, which can be explained by an inability to degrade the neuronal repressor, Tramtrack. I find no evidence for redundancy in the function of Sina and SinaH.
DOI	10.1016/j.mod.2007.04.007
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Secondary IDs
Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Mech. Dev.
Title	Mechanisms of Development
Publication Year	1990-
ISBN/ISSN	0925-4773
Data from Reference
Aberrations (1)
	Df(3L)sina^SH
Alleles (9)
	ebi^k16213 phyl² sina² sina³ sina^BG02648 sina^SH sinah¹ sinah^SH w^+mW.hs
Constructs (3)
	P{FRT(sina^SH.Scer\SceI.RS)} P{FRT(sinah¹.Scer\SceI.RS)} pP{W25}
Genes (6)
	CG13029 ebi phyl Rh4 sina sinah
Insertions (1)
	P{GT1}sina^BG02648
Natural transposons (1)
	P-element