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Reference
Citation
Bejarano, F., Pérez, L., Apidianakis, Y., Delidakis, C., Milán, M. (2007). Hedgehog restricts its expression domain in the Drosophila wing.  EMBO Rep. 8(8): 778--783.
FlyBase ID
FBrf0200898
Publication Type
Research paper
Abstract

The stable subdivision of Drosophila limbs into anterior and posterior compartments is a consequence of asymmetrical signalling by Hedgehog (Hh), from the posterior to anterior cells. The activity of the homeodomain protein Engrailed in posterior cells helps to generate this asymmetry by inducing the expression of Hh in the posterior compartment and, at the same time, repressing the expression of the essential downstream component Cubitus interruptus (Ci). Therefore, only anterior cells that receive the Hh signal across the compartment boundary will respond by stabilizing Ci. Here, we describe a new molecular mechanism that helps to maintain the Hh-expressing and Hh-responding cells in different non-overlapping cell populations. Master of thickveins (mtv) - a target of Hh activity encoding a nuclear zinc-finger protein - is required to repress hh expression in anterior cells. Mtv exerts this action in a protein complex with Groucho (Gro) - the founding member of a superfamily of transcriptional corepressors that are conserved throughout eukaryotes. Therefore, Hh restricts its own expression domain in the Drosophila wing through the activity of Mtv and Gro.

PubMed ID
PubMed Central ID
PMC1978085 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    EMBO Rep.
    Title
    EMBO Reports
    Publication Year
    2000-
    ISBN/ISSN
    1469-221X 1469-3178
    Data From Reference
    Aberrations (2)
    Alleles (16)
    Genes (16)
    Physical Interactions (5)
    Cell Lines (1)
    Insertions (6)
    Transgenic Constructs (4)