Reference Report

Reference
Citation	Lecuyer, E., Yoshida, H., Parthasarathy, N., Alm, C., Babak, T., Cerovina, T., Hughes, T.R., Tomancak, P., Krause, H.M. (2007). Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function. Cell 131(1): 174--187. (Export to RIS)
FlyBase ID	FBrf0200939
Publication Type	Research paper
PubMed ID	17923096
PubMed Abstract	Although subcellular mRNA trafficking has been demonstrated as a mechanism to control protein distribution, it is generally believed that most protein localization occurs subsequent to translation. To address this point, we developed and employed a high-resolution fluorescent in situ hybridization procedure to comprehensively evaluate mRNA localization dynamics during early Drosophila embryogenesis. Surprisingly, of the 3370 genes analyzed, 71% of those expressed encode subcellularly localized mRNAs. Dozens of new and striking localization patterns were observed, implying an equivalent variety of localization mechanisms. Tight correlations between mRNA distribution and subsequent protein localization and function, indicate major roles for mRNA localization in nucleating localized cellular machineries. A searchable web resource documenting mRNA expression and localization dynamics has been established and will serve as an invaluable tool for dissecting localization mechanisms and for predicting gene functions and interactions.
DOI	10.1016/j.cell.2007.08.003
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Genes (85)
	Ama aret asp aur bcd bib BicD Bsg25D Btk29A Bub1 cas cathD Cen CG4500 CG8552 CG14438 CG15634 CG42232 cnn cno cp309 crb crn CycA CycB Cyt-b5 dlg1 eIF5 Eip71CD fra gcl Gp150 grp gwl h hb hrg htl IA-2 Imp Jra kis kuk l(1)G0289 lok mfas milt mira nos nullo odd orb osk pAbp Patj prd pros Prp8 Ptr pum raps Rbp1 rib roX1 run scb scra scw SmD1 SmD3 smo snRNP-U1-70K sog spir Ste12DOR stwl Su(var)3-9 Taf4 Tm1 Trn-SR ttk U2af50 ush verm wg
Natural transposons (2)
	copia Doc