Reference Report

Reference
Citation	Parrish, J.Z., Emoto, K., Jan, L.Y., Jan, Y.N. (2007). Polycomb genes interact with the tumor suppressor genes hippo and warts in the maintenance of Drosophila sensory neuron dendrites. Genes Dev. 21(8): 956--972. (Export to RIS)
FlyBase ID	FBrf0201136
Publication Type	Research paper
PubMed ID	17437999
PubMed Abstract	Dendritic fields are important determinants of neuronal function. However, how neurons establish and then maintain their dendritic fields is not well understood. Here we show that Polycomb group (PcG) genes are required for maintenance of complete and nonoverlapping dendritic coverage of the larval body wall by Drosophila class IV dendrite arborization (da) neurons. In esc, Su(z)12, or Pc mutants, dendritic fields are established normally, but class IV neurons display a gradual loss of dendritic coverage, while axons remain normal in appearance, demonstrating that PcG genes are specifically required for dendrite maintenance. Both multiprotein Polycomb repressor complexes (PRCs) involved in transcriptional silencing are implicated in regulation of dendrite arborization in class IV da neurons, likely through regulation of homeobox (Hox) transcription factors. We further show genetic interactions and association between PcG proteins and the tumor suppressor kinase Warts (Wts), providing evidence for their cooperation in multiple developmental processes including dendrite maintenance.
DOI	10.1101/gad.1514507
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Language of Publication	English
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Parent Publication
Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Alleles (47)
	abd-A^Scer\UAS.cGa Antp²⁵ Antp^Ns-rvC3 Avic\GFP^1.E.ppk B-H1^Scer\UAS.cUa B-H2^Scer\UAS.cUa cad² chic²²¹ CtBP⁰³⁴⁶³ cv-2¹ disco¹ E(z)⁶³ Ecol\lacZ^E7-2-36 esc²¹ esc^Scer\UAS.cUa fas⁰⁵⁴⁸⁸ hpo^MGH4 hth^5E04 klg^rN712 lbe^Df311 Map205^KG05618 Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Pc¹ Pc³ Pc¹⁵ pnr¹ salm¹ sav³ Scer\GAL4²²¹ Scer\GAL4^elav-C155 Scer\GAL4^ppk.PG Scr^C1 seq²² Su(z)12¹ Su(z)12² Su(z)12⁴ Su(z)12⁵ Tab2^201Y Ten-m⁰⁵³⁰⁹ tll^l49 tomosyn^EP1359 trh² Ubx¹ Ubx^MX12 Ubx^Scer\UAS.cUa vg^Scer\UAS.cUa wts^x1
Constructs (9)
	P{ppk-EGFP.1} P{ppk-GAL4.G} P{UAS-abd-A.G} P{UAS-B-H1.U} P{UAS-B-H2.U} P{UAS-esc.U} P{UAS-mCD8::GFP.L} P{UAS-Ubx.U} P{UAS-vg.U}
Genes (43)
	ab abd-A Abd-B Antp Avic\GFP B-H1 B-H2 cad chic ct CtBP cv-2 disco E(z) Ecol\lacZ esc fas fry hpo hth klg lbe Map205 Mmus\Cd8a nos Pc pnr pum Rac1 salm sav Scer\GAL4 Scr seq Su(z)12 Tab2 Ten-m tll tomosyn trh Ubx vg wts
Insertions (1)
	P{GawB}elav^C155
Natural transposons (1)
	P-element