Reference Report

Reference
Citation	Hughes, C.L., Thomas, J.B. (2007). A sensory feedback circuit coordinates muscle activity in Drosophila. Mol. Cell. Neurosci. 35(2): 383--396. (Export to RIS)
FlyBase ID	FBrf0201151
Publication Type	Research paper
PubMed ID	17498969
PubMed Abstract	Drosophila larval crawling is a simple behavior that allows us to dissect the functions of specific neurons in the intact animal and explore the roles of genes in the specification of those neurons. By inhibiting subsets of neurons in the PNS, we have found that two classes of multidendritic neurons play a major role in larval crawling. The bipolar dendrites and class I mds send a feedback signal to the CNS that keeps the contraction wave progressing quickly, allowing smooth forward movement. Genetic manipulation of the sensory neurons suggests that this feedback depends on proper dendritic morphology and axon pathfinding to appropriate synaptic target areas in the CNS. Our data suggest that coordination of muscle activity in larval crawling requires feedback from neurons acting as proprioceptors, sending a "mission accomplished" signal in response to segment contraction, and resulting in rapid relaxation of the segment and propagation of the wave.
DOI	10.1016/j.mcn.2007.04.001
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Mol. Cell. Neurosci.
Title	Molecular and Cellular Neurosciences
Publication Year	1990-
ISBN/ISSN	1044-7431
Data from Reference
Alleles (21)
	Avic\GFP^Mhc-C110 ct^Scer\UAS.cPa Ctet\TeTxLC^TNT.Scer\UAS Disc\RFP^{DsRedT4.Scer\UAS.T:nls-tra} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Scer\GAL4^2-21 Scer\GAL4^5-40 Scer\GAL4^7-33 Scer\GAL4^8-73 Scer\GAL4^8-113 Scer\GAL4^9-20 Scer\GAL4^109(2)80 Scer\GAL4^1003.3 Scer\GAL4^clh8 Scer\GAL4^clh24 Scer\GAL4^clh201 Scer\GAL4^NP2225 Scer\GAL4^NP5092 Scer\GAL4^scrt-11-6 shi^1.Scer\UAS unc-5^Scer\UAS.cKa
Constructs (8)
	P{GawB} P{PTT-un1} P{UAS-ct.P} P{UAS-mCD8::GFP.L} P{UAS-RedStinger} P{UAS-shi^ts1.K} P{UAS-TeTxLC.tnt} P{UAS-unc-5.K}
Genes (10)
	Avic\GFP ct Ctet\TeTxLC Disc\RFP Mhc Mmus\Cd8a Scer\GAL4 scrt shi unc-5
Insertions (15)
	P{GAL4}5-40 P{GawB}2-21 P{GawB}7-33 P{GawB}8-73 P{GawB}8-113 P{GawB}9-20 P{GawB}109(2)80 P{GawB}1003.3 P{GawB}ab^NP2225 P{GawB}clh8 P{GawB}clh24 P{GawB}clh201 P{GawB}egh^NP5092 P{GawB}scrt^11-6 P{PTT-un1}Mhc^C110
Natural transposons (1)
	P-element
Transcripts (14)
	Scer\GAL4^2-21RA Scer\GAL4^5-40RA Scer\GAL4^7-33RA Scer\GAL4^8-73RA Scer\GAL4^8-113RA Scer\GAL4^9-20RA Scer\GAL4^109(2)80RA Scer\GAL4^1003.3RA Scer\GAL4^clh8RA Scer\GAL4^clh24RA Scer\GAL4^clh201RA Scer\GAL4^NP2225RA Scer\GAL4^NP5092RA Scer\GAL4^scrt-11-6RA