Reference Report

Reference
Citation	Weiler, K.S. (2007). E(var)3-9 of Drosophila melanogaster Encodes a Zinc Finger Protein. Genetics 177(1): 167--178. (Export to RIS)
FlyBase ID	FBrf0201244
Publication Type	Research paper
PubMed ID	17660546
PubMed Abstract	The importance of a gene's natural chromatin environment for its normal expression is poignantly illustrated when a change in chromosome position results in variable gene repression, such as is observed in position effect variegation (PEV) when the Drosophila melanogaster white (omega) gene is juxtaposed with heterochromatin. The Enhancer of variegation 3-9 [E(var)3-9] gene was one of over a hundred loci identified in screens for mutations that dominantly modify PEV. Haploinsufficiency for E(var)3-9 enhances omegam4 variegation, as would be expected from increased heterochromatin formation. To clarify the role of E(var)3-9 in chromosome structure, the gene has been cloned and its mutant alleles characterized. The involvement of E(var)3-9 in structure determination was supported by its reciprocal effects on euchromatic and heterochromatic PEV; E(var)3-9 mutations increased expression of a variegating heterochromatic gene in two tissue types. E(var)3-9 mutations also had a recessive phenotype, maternal effect lethality, which implicated E(var)3-9 function in an essential process during embryogenesis. Both phenotypes of E(var)3-9 mutations were consistent with its proposed function in promoting normal chromosome structure. The cloning of E(var)3-9 by classical genetic methods revealed that it encodes a protein with multiple zinc fingers, but otherwise novel sequence.
DOI	10.1534/genetics.107.076521
Related Publication(s)
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Genetics
Title	Genetics
Publication Year	1916-
ISBN/ISSN	0016-6731
Data from Reference
Aberrations (28)
	Df(2L)lt10 Df(3R)BSC24 Df(3R)by10 Df(3R)by62 Df(3R)cu Df(3R)ED5301 Df(3R)ED5331 Df(3R)Exel6151 Df(3R)Exel6152 Df(3R)M86D Df(3R)M-Kx1 Df(3R)p819 Df(3R)p-XT103 Df(3R)w⁺y^-18 Df(3R)w⁺y^-124 Df(3R)w^-y⁺5 Df(3R)w^-y⁺12 Df(3R)w^-y⁺14 Df(3R)w^-y⁺21 Df(3R)w^-y⁺96 Df(3R)w^-y⁺136 Dp(3;3)w⁺y^-38 Dp(3;3)w⁺y^-188 In(1)w^m4 In(2L)lt^X2 In(2LR)lt^G10 In(3LR)TM6B T(2;3)Sb^V
Alleles (9)
	E(var)3-9¹ E(var)3-9² E(var)3-9³ E(var)3-9^DG08508 E(var)3-9^DG08508w- E(var)3-9^unspecified E(var)3-9^Δ149 lt¹ y⁺
Balancers (1)
	TM6B
Constructs (3)
	P{3'wHy} P{5'wHy} P{wHy-ΔDG08508w-}
Genes (47)
	Aats-trp Ada beag CAHβ CG8420 CG8436 CG8861 CG9740 CG11964 CG11966 CG11970 CG11975 CG11977 CG11980 CG11982 CG11983 CG11984 CG11985 CG11986 CG11997 CG16734 CG16736 CG31100 CR16735 cu D1 E(var)3-9 hyx ird1 Kdm2 lt Mst85C neur Nmdmc osk p Prosβ3 pum pyd RagA-B Rel sage skap St2 tgo VhaM8.9 Vps16A
Insertions (13)
	P{3'wHy}E(var)3-9^Δ149 P{3'wHy}w^-y⁺5 P{3'wHy}w^-y⁺12 P{3'wHy}w^-y⁺14 P{3'wHy}w^-y⁺21 P{3'wHy}w^-y⁺96 P{3'wHy}w^-y⁺136 P{5'wHy}w⁺y^-18 P{5'wHy}w⁺y^-38 P{5'wHy}w⁺y^-124 P{5'wHy}w⁺y^-188 P{wHy}E(var)3-9^DG08508 P{wHy-ΔDG08508w-}E(var)3-9^DG08508w-
Natural transposons (1)
	P-element