Reference Report

Reference
Citation	Li, W., Baker, N.E. (2007). Engulfment is required for cell competition. Cell 129(6): 1215--1225. (Export to RIS)
FlyBase ID	FBrf0201270
Publication Type	Research paper
PubMed ID	17574031
PubMed Abstract	Genetic mosaics that place cells in competition within tissues may model features of tissue repair and tumor development and may reveal mechanisms of growth regulation. In one example, normal cells eliminate "Minute" cells that have reduced ribosomal protein gene dose and grow at their expense, replacing the Minute cells within developing compartments. We describe genes that are required by wild-type cells to kill Minute neighbors in Drosophila. The engulfment genes draper, wasp, the phosphatidylserine receptor, mbc/dock180, and rac1 are needed in wild-type cells for the death of Minute neighbors, whose corpses are engulfed by wild-type cells. Wild-type cells can themselves be killed by cells with elevated engulfing activity. Thus engulfment genes act downstream of growth differences between cells to eliminate cells with reduced ribosomal gene dose.
DOI	10.1016/j.cell.2007.03.054
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Aberrations (1)
	Ts(1Rt;2Rt)Bld
Alleles (19)
	Avic\GFP^Scer\UAS.cUa BacA\p35^Scer\UAS.cHa dm^Scer\UAS.cZa drpr^Δ5 Hem^{Scer\UAS.T:Myr-Src64B} M(2)56F^unspecified M(3)96C^unspecified mbc^EY01437 PSR^EY07193 PSR^null Rac1^EY05848 RpL27A^unspecified RpS17^unspecified SCAR^Δ37 Scer\GAL4^Act5C.PP Scer\GAL4^en-e16E Scer\GAL4^{Scer\FRT.Rnor\CD2.Act5C} WASp¹ WASp^EY06238
Constructs (5)
	P{GAL4-Act5C(FRT.CD2).P} P{UAS-dm.Z} P{UAS-GFP.U} P{UAS-Hem.Myr} P{UAS-p35.H}
Genes (16)
	Avic\GFP BacA\p35 dm drpr Hem His3 M(2)56F M(3)96C mbc PSR Rac1 RpL27A RpS17 SCAR Scer\GAL4 WASp
Insertions (2)
	P{en2.4-GAL4}e16E P{EPgy2}PSR^EY07193