Reference Report

Reference
Citation	Lin, H.H., Lai, J.S.Y., Chin, A.L., Chen, Y.C., Chiang, A.S. (2007). A map of olfactory representation in the Drosophila mushroom body. Cell 128(6): 1205--1217. (Export to RIS)
FlyBase ID	FBrf0201372
Publication Type	Research paper
PubMed ID	17382887
PubMed Abstract	Neural coding for olfactory sensory stimuli has been mapped near completion in the Drosophila first-order center, but little is known in the higher brain centers. Here, we report that the antenna lobe (AL) spatial map is transformed further in the calyx of the mushroom body (MB), an essential olfactory associated learning center, by stereotypic connections with projection neurons (PNs). We found that Kenyon cell (KC) dendrites are segregated into 17 complementary domains according to their neuroblast clonal origins and birth orders. Aligning the PN axonal map with the KC dendritic map and ultrastructural observation suggest a positional ordering such that inputs from the different AL glomeruli have distinct representations in the MB calyx, and these representations might synapse on functionally distinct KCs. Our data suggest that olfactory coding at the AL is decoded in the MB and then transferred via distinct lobes to separate higher brain centers.
DOI	10.1016/j.cell.2007.03.006
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell
Title	Cell
Publication Year	1974-
ISBN/ISSN	0092-8674
Data from Reference
Alleles (17)
	Mmus\Cd8a^{Scer\FRT.Scer\UAS.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.S.T:Avic\GFP} Mmus\Cd8a^{Scer\UAS.T:Avic\GFP} Rnor\CD2^{Scer\UAS.T:Arus\HRP,T:SS-wg} Scer\GAL4^c44a Scer\GAL4^c305a Scer\GAL4^c708a Scer\GAL4^ey-OK107 Scer\GAL4^G0013 Scer\GAL4^G0050 Scer\GAL4^G0116 Scer\GAL4^G0391 Scer\GAL4^G0451 Scer\GAL4^GH146 Scer\GAL4^H24 Scer\GAL4^Mz19 Scer\GAL4^P0003
Constructs (5)
	P{GAL4} P{UAS(FRT.CD2.y⁺)CD8-GFP} P{UAS(-FRT)CD8-GFP} P{UAS-CD2::HRP} P{UAS-mCD8::GFP.L}
Genes (3)
	Mmus\Cd8a Rnor\CD2 Scer\GAL4
Insertions (13)
	P{GAL4}c708a P{GAL4}G0013 P{GAL4}G0050 P{GAL4}G0116 P{GAL4}G0391 P{GAL4}G0451 P{GAL4}H24 P{GAL4}P0003 P{GawB}c44a P{GawB}c305a P{GawB}ey^OK107 P{GawB}GH146 P{GawB}Mz19
Transcripts (7)
	Scer\GAL4^c44aRA Scer\GAL4^c708aRA Scer\GAL4^G0050RA Scer\GAL4^G0116RA Scer\GAL4^G0391RA Scer\GAL4^G0451RA Scer\GAL4^Mz19RA