Reference Report

Reference
Citation	Duan, H., Zhang, C., Chen, J., Sink, H., Frei, E., Noll, M. (2007). A key role of Pox meso in somatic myogenesis of Drosophila. Development 134(22): 3985--3997. (Export to RIS)
FlyBase ID	FBrf0201381
Publication Type	Research paper
PubMed ID	17942482
PubMed Abstract	The Pax gene Pox meso (Poxm) was the first and so far only gene whose initial expression was shown to occur specifically in the anlage of the somatic mesoderm, yet its role in somatic myogenesis remained unknown. Here we show that it is one of the crucial genes regulating the development of the larval body wall muscles in Drosophila. It has two distinct functions expressed during different phases of myogenesis. The early function, partially redundant with the function of lethal of scute [l(1)sc], demarcates the ;Poxm competence domain', a domain of competence for ventral and lateral muscle development and for the determination of at least some adult muscle precursor cells. The late function is a muscle identity function, required for the specification of muscles DT1, VA1, VA2 and VA3. Our results led us to reinterpret the roles of l(1)sc and twist in myogenesis and to propose a solution of the 'l(1)sc conundrum'.
DOI	10.1242/dev.008821
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Development
Title	Development
Publication Year	1987-
ISBN/ISSN	0950-1991
Data from Reference
Aberrations (4)
	Df(1)sc19 Df(3R)159 Df(3R)dsx5 Df(3R)dsx29
Alleles (15)
	Avic\GFP^{S65T.Mhc.T:Btau\MAPT} Avic\GFP^{Scer\UAS.T:SV40\nls2} Ecol\lacZ^kirre-rP298 Ecol\lacZ^Poxm.1.8 Ecol\lacZ^Poxm.8.4 Ecol\lacZ^Scer\UAS.cBa lmd¹ Mef2^22-21 Poxm^R361 Poxm^Scer\UAS.cJa Poxm^um1-2 Scer\GAL4^how-24B Scer\GAL4^Poxm.1.8 Scer\GAL4^Poxm.8.4 w^+mW.hs
Constructs (9)
	P{Mhc-tauGFP} P{Poxm-GAL4.1.8} P{Poxm-GAL4.8.4} P{Poxm-lacZ.1.8} P{Poxm-lacZ.8.4} P{UAS-GFP.nls} P{UAS-lacZ.B} P{UAS-Poxm.J} P{um1-2-Poxm}
Genes (13)
	Avic\GFP Ecol\lacZ kirre l(1)sc lmd Mef2 Mhc Poxm Scer\GAL4 slou tin twi w
Insertions (3)
	P{GawB}how^24B P{lacW}P282 P{PZ}rP298
Natural transposons (1)
	P-element