Reference Report

Reference
Citation	Bender, W. (2008). MicroRNAs in the Drosophila bithorax complex. Genes Dev. 22(1): 14--19. (Export to RIS)
FlyBase ID	FBrf0201387
Publication Type	Research paper
PubMed ID	18172161
PubMed Abstract	The iab-4 noncoding RNA from the Drosophila bithorax complex is the substrate for a microRNA (miRNA). Gene conversion was used to delete the hairpin precursor of this miRNA; flies homozygous for this deletion are sterile. Surprisingly, this mutation complements with rearrangement breakpoint mutations that disrupt the iab-4 RNA but fails to complement with breaks mapping in the iab-5 through iab-7 regulatory regions. These breaks disrupt the iab-8 RNA, transcribed from the opposite strand. This iab-8 RNA also encodes a miRNA, detected on Northern blots, derived from the hairpin complementary to the iab-4 precursor hairpin. Ultrabithorax is a target of both miRNAs, although its repression is subtle in both cases.
DOI	10.1101/gad.1614208
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Language of Publication	English
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Publication Type	Journal
Abbreviation	Genes Dev.
Title	Genes & Development
Publication Year	1987-
ISBN/ISSN	0890-9369
Data from Reference
Aberrations (18)
	Ab(?;3)iab3^86A Ab(?;3)iab3⁵⁰²² Ab(?;3)iab3^B1 Ab(?;3)iab-4¹⁸⁶ Ab(?;3)iab4²³³⁰ Df(3R)ΔmiRNA Df(Ab;3)iab4.5³²⁴⁵ In(3LR)iab3³³ In(3R)iab6^G In(3R)iab7^SGA In(3R)iab7^Spth In(3R)iab9^Uab1 T(2;3;4)iab4³⁰² T(2;3)iab4⁴⁵ T(2;3)iab6¹⁰⁵ T(2;3)iab9⁶⁵ Tp(3;2)iab5⁸⁴³ Tp(3;Y)Abd-B^S10
Alleles (2)
	abd-A^D100.24 Abd-B^HCJ199
Constructs (1)
	P{ΔmiRNA.donor}
Genes (7)
	abd-A Abd-B iab-4 iab-8 mir-iab-4 mir-iab-8 Ubx
Insertions (1)
	P{(-FRT)lacZ.HP}Abd-B^HCJ199