Reference Report

Reference
Citation	Firth, L.C., Baker, N.E. (2007). Spitz from the retina regulates genes transcribed in the second mitotic wave, peripodial epithelium, glia and plasmatocytes of the Drosophila eye imaginal disc. Dev. Biol. 307(2): 521--538. (Export to RIS)
FlyBase ID	FBrf0201413
Publication Type	Research paper
PubMed ID	17553483
PubMed Abstract	Proliferation, differentiation, and other processes must be coordinated during the development of multi-cellular animals. A discrete and regulated cell division, the Second Mitotic Wave (SMW), occurs concomitantly with early cell fate decisions in the Drosophila developing retina. Signals from the Epidermal Growth Factor Receptor (EGFR) are required to promote cell cycle arrest of specified cells and antagonize S-phase entry in the SMW. Cells that do not receive any EGFR activity enter S-phase in the SMW in response to the Notch pathway. To identify genes with potential roles in the SMW, we used microarrays and genetic manipulation of the EGFR pathway to seek transcripts regulated during the SMW. RNA in situ hybridization of 126 differentially transcribed genes revealed genes that have novel expression patterns in cells closely associated with the SMW. In addition, other genes' transcripts were regulated in the differentiating photoreceptor cells, retinal basal glia, the peripodial epithelium and blood cells (plasmatocytes) associated with the developing retina. These novel targets suggest that during eye development, EGFR activity coordinates transcriptional programs in other tissues with retinal differentiation.
DOI	10.1016/j.ydbio.2007.04.037
Related Publication(s)
Erratum	Corrigendum. Firth and Baker, 2009, Dev. Biol. 325(1): 307 [FBrf0211369]
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Associated Information
Comments
Associated Files
Other Information
Secondary IDs
Language of Publication	English
Additional Languages of Abstract
Also Published As
Parent Publication
Publication Type	Journal
Abbreviation	Dev. Biol.
Title	Developmental Biology
Publication Year	1959-
ISBN/ISSN	0012-1606
Data from Reference
Alleles (3)
	Ras85D^V12.Scer\UAS Scer\GAL4^GMR.PF spi^s.Scer\UAS
Constructs (3)
	P{GAL4-ninaE.GMR} P{UAS-Ras85D.V12} P{UAS-spi.s}
Genes (126)
	a al Aplip1 arm ato beat-Ic B-H1 bib Brd brp CAP CG3523 CG3781 CG3893 CG4096 CG4408 CG4686 CG4914 CG5653 CG7900 CG8483 CG8965 CG9134 CG9336 CG9416 CG11073 CG11382 CG13041 CG13203 CG13532 CG13606 CG13890 CG14275 CG14567 CG14598 CG15370 CG15522 CG15630 CG15911 CG17278 CG17919 CG18278 CG18547 CG18600 CG30022 CG31176 CG31291 CG31676 CG32354 CG32406 CG33275 CG34347 CG34371 CG34398 CG42313 CG43861 Clect27 cpo Cpr49Ac CR18854 CycB Cyp4e2 dbe disco-r Dscam E(spl)m2-BFM egr elav Fas2 Fhos GM130 Ir21a Ir40a kek1 klg Lim1 Lip1 lz magu Meltrin miple Mob2 MP1 mthl8 nonC Nrg Obp44a Osi23 Pde8 PGRP-SC2 pnt Ppn Prosα1 pyr Rac2 Ras85D repo rn robl62A robo scb Scer\GAL4 scrib sda Sep4 SKIP Sox100B SoxN SP1029 SP2353 spi Spn43Aa sqz ss Sulf1 svp T48 ths Traf4 trn Tsp42El tun twe Ugt86Di wbl βTub60D