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Reference Report
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| Citation | Goshima, G., Wollman, R., Goodwin, S.S., Zhang, N., Scholey, J.M., Vale, R.D., Stuurman, N. (2007). Genes required for mitotic spindle assembly in Drosophila S2 cells. Science 316(5823): 417--421. (Export to RIS) | ||
| FlyBase ID | FBrf0201458 | ||
| Publication Type | Research paper | ||
| PubMed ID | 17412918 | ||
| PubMed Abstract | The formation of a metaphase spindle, a bipolar microtubule array with centrally aligned chromosomes, is a prerequisite for the faithful segregation of a cell's genetic material. Using a full-genome RNA interference screen of Drosophila S2 cells, we identified about 200 genes that contribute to spindle assembly, more than half of which were unexpected. The screen, in combination with a variety of secondary assays, led to new insights into how spindle microtubules are generated; how centrosomes are positioned; and how centrioles, centrosomes, and kinetochores are assembled. | ||
| DOI | 10.1126/science.1141314 | ||
| Related Publication(s) | |||
| Supplementary material | Supporting online material for Genes required for mitotic spindle assembly in Drosophila S2 cells. [FBrf0200397] |
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| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
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Other Information
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| Language of Publication | English | ||
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Parent Publication
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| Publication Type | Journal | ||
| Abbreviation | Science | ||
| Title | Science | ||
| Publication Year | 1895- | ||
| ISBN/ISSN | 0036-8075 | ||
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Data from Reference
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| Alleles (8)
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| Genes (48)
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