Reference Report

Reference
Citation	Wu, J., Randle, K.E., Wu, L.P. (2007). ird1 is a Vps15 homologue important for antibacterial immune responses in Drosophila. Cell. Microbiol. 9(4): 1073--1085. (Export to RIS)
FlyBase ID	FBrf0201559
Publication Type	Research paper
PubMed ID	17166233
PubMed Abstract	The immune response-deficient 1 (ird1) gene was identified in a forward genetic screen as a novel regulator for the activation of Imd NFkappaB immune signalling pathway in Drosophila. ird1 animals are also more susceptible to Escherichia coli and Micrococcus luteus bacterial infection. ird1 encodes the Drosophila homologue of the Vps15/p150 serine/threonine kinase that regulates a class III phosphoinositide 3-kinase and is necessary for phagosome maturation and starvation-induced autophagy in yeast and mammalian cells. To gain insight into the role of ird1 in the immune response, we examine how amino acid starvation affects the immune signalling pathways in Drosophila. Starvation, in the absence of infection, leads to expression of antimicrobial peptide (AMP) genes and this response is dependent on ird1 and the Imd immune signalling pathway. Starvation, in addition to bacterial infection, suppresses the AMP response in wild-type animals and reduces the ability to survive M. luteus infection. Our results suggest that starvation and innate immune signalling may be intimately linked processes.
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Secondary IDs	FBrf0193842
Language of Publication	English
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Publication Type	Journal
Abbreviation	Cell. Microbiol.
Title	Cellular Microbiology
Publication Year	1999-
ISBN/ISSN	1462-5814
Data from Reference
Aberrations (3)
	Df(2L)J4 Df(3R)ro-XB3 Df(3R)Tl-X
Alleles (34)
	beag^EP3260 cact⁷ cact²⁵⁵ CG11966^KG07310 CG11970^EP501 D1^EP473 Dif¹ Dredd^Scer\UAS.cVa EP643^EP643 imd^Scer\UAS.cGa ird1¹ ird1² ird1³ ird1⁴ ird1⁵ ird1⁶ ird1⁷ ird1^Scer\UAS.cWa Kdm2^EP3198 Kdm2^EP3396 Kdm2^EP3737 l(3)S042008^S042008 l(3)S089904^S089904 l(3)S093614^S093614 neur^S129309 neur^S131505 PGRP-LE^{Scer\UAS.T:Zzzz\FLAG} pum^KG05749 Rel^E20 Rel^KG07752 Scer\GAL4^c564 spz⁴ Tak1^Scer\UAS.cTa w^+mC
Constructs (5)
	P{UAS-Dredd.V} P{UAS-imd.G} P{UAS-ird1.W} P{UAS-PGRP-LE.FLAG} P{UAS-Tak1}
Genes (38)
	Ada AttA AttB AttC AttD beag cact CecA1 CecA2 CG11966 CG11970 D1 Def Dif Dpt Dredd Dro Drs EP643 hyx imd ird1 Kdm2 l(3)S042008 l(3)S089904 l(3)S093614 Mst85C Mtk neur Nmdmc PGRP-LE pum Rel Scer\GAL4 spz Tak1 Tl w
Insertions (3)
	P{EP}D1^EP473 P{GawB}c564 P{UAS-ird1.W}PA10-68